SARS‐CoV‐2 NSP8 suppresses type I and III IFN responses by modulating the RIG‐I/MDA5, TRIF, and STING signaling pathways

J Deng, SN Zheng, Y Xiao, ML Nan… - Journal of Medical …, 2023 - Wiley Online Library
SARS‐CoV‐2 has developed a variety of approaches to counteract host innate antiviral
immunity to facilitate its infection, replication and pathogenesis, but the molecular …

SARS‐CoV‐2 NSP7 inhibits type I and III IFN production by targeting the RIG‐I/MDA5, TRIF, and STING signaling pathways

J Deng, Y Zheng, SN Zheng, ML Nan… - Journal of Medical …, 2023 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is a poor inducer of innate
antiviral immunity, and the underlying mechanism still needs further investigation. Here, we …

SARS‐CoV‐2 ORF9b antagonizes type I and III interferons by targeting multiple components of the RIG‐I/MDA‐5–MAVS, TLR3–TRIF, and cGAS–STING signaling …

L Han, MW Zhuang, J Deng, Y Zheng… - Journal of medical …, 2021 - Wiley Online Library
The suppression of types I and III interferon (IFN) responses by severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2) contributes to the pathogenesis of coronavirus …

SARS-CoV-2 NSP5 and N protein counteract the RIG-I signaling pathway by suppressing the formation of stress granules

Y Zheng, J Deng, L Han, MW Zhuang, Y Xu… - Signal transduction and …, 2022 - nature.com
As a highly pathogenic human coronavirus, SARS-CoV-2 has to counteract an intricate
network of antiviral host responses to establish infection and spread. The nucleic acid …

SARS-CoV-2 nucleocapsid protein targets RIG-I-like receptor pathways to inhibit the induction of interferon response

SJ Oh, OS Shin - Cells, 2021 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the coronavirus disease 2019 (COVID-19) that has resulted in the current pandemic. The …

SARS‐CoV‐2 NSP13 interacts with host IRF3, blocking antiviral immune responses

K Feng, HJ Zhang, YQ Min, M Zhou… - Journal of Medical …, 2023 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2), poses an unprecedented threat to human health …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling

Y Zheng, MW Zhuang, L Han, J Zhang… - Signal transduction and …, 2020 - nature.com
Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has quickly spread worldwide and has affected …

Roles and functions of SARS-CoV-2 proteins in host immune evasion

F Rashid, Z Xie, M Suleman, A Shah, S Khan… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evades the host immune
system through a variety of regulatory mechanisms. The genome of SARS-CoV-2 encodes …

SARS-CoV-2 nsp12 attenuates type I interferon production by inhibiting IRF3 nuclear translocation

W Wang, Z Zhou, X Xiao, Z Tian, X Dong… - Cellular & molecular …, 2021 - nature.com
SARS-CoV-2 is the pathogenic agent of COVID-19, which has evolved into a global
pandemic. Compared with some other respiratory RNA viruses, SARS-CoV-2 is a poor …

SARS-CoV-2 viral proteins NSP1 and NSP13 inhibit interferon activation through distinct mechanisms

C Vazquez, SE Swanson, SG Negatu, M Dittmar… - PloS one, 2021 - journals.plos.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a devastating
global pandemic, infecting over 43 million people and claiming over 1 million lives, with …