Background Serotonin reuptake inhibitors (SRIs) effectively treat both major depressive
disorder (MDD) and obsessive-compulsive disorder (OCD). We compared and contrasted …

OBJECTIVE: Serotonin reuptake inhibitor (SRI) medications are effective in the treatment of
both major depressive disorder and obsessive-compulsive disorder (OCD), but it is unknown …

Previous positron emission tomography (PET) studies of patients with obsessive-compulsive
disorder (OCD) have found elevated glucose metabolic rates in the orbitofrontal cortex …

Cognitive behavioral therapy (CBT) and selective serotonin reuptake inhibitors (SSRIs) are
both effective treatments for some patients with obsessive-compulsive disorder (OCD), yet …

Background: The frequent comorbidity of major depressive disorder (MDD) and obsessive-
compulsive disorder (OCD) suggests a fundamental relationship between them. We sought …

Functional brain imaging studies of subjects with Major Depressive Disorder (MDD) have
suggested that decreased dorsolateral (DLPFC) and increased ventrolateral (VLPFC) …

We examined the effects of sertraline and of desipramine on patients with OCD and
comorbid major depressive episodes at study entry. Sixteen patients, 9 receiving sertraline …

In subjects with obsessive-compulsive disorder (OCD), lower pre-treatment metabolism in
the right orbitofrontal cortex (OFC) and anterior cingulate gyrus (AC) has been associated …

The regional metabolic effects of fluoxetine were examined in patients with autism spectrum
disorders. Six adult patients with DSM-IV and Autism Diagnostic Interview (ADI) diagnoses …

Several neuroimaging studies of patients with OCD have pointed to basal ganglia and the
frontal cortical regions being relevant for an understanding of the pathophysiology and …