A quarter century of APOE and Alzheimer's disease: progress to date and the path forward
Alzheimer's disease (AD) is considered a polygenic disorder. This view is clouded, however,
by lingering uncertainty over how to treat the quasi" monogenic" role of apolipoprotein E …
by lingering uncertainty over how to treat the quasi" monogenic" role of apolipoprotein E …
Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies
Polymorphism in the apolipoprotein E (APOE) gene is a major genetic risk determinant of
late-onset Alzheimer disease (AD), with the APOE* ε 4 allele conferring an increased risk …
late-onset Alzheimer disease (AD), with the APOE* ε 4 allele conferring an increased risk …
The role of APOE4 in Alzheimer's disease: strategies for future therapeutic interventions
HC Hunsberger, PD Pinky, W Smith… - Neuronal …, 2019 - portlandpress.com
Alzheimer's disease (AD) is the leading cause of dementia affecting almost 50 million
people worldwide. The ε4 allele of Apolipoprotein E (APOE) is the strongest known genetic …
people worldwide. The ε4 allele of Apolipoprotein E (APOE) is the strongest known genetic …
ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies
AC Raulin, SV Doss, ZA Trottier, TC Ikezu, G Bu… - Molecular …, 2022 - Springer
Alzheimer's disease (AD) is the most common cause of dementia worldwide, and its
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …
Cell type-specific roles of APOE4 in Alzheimer disease
The ɛ4 allele of the apolipoprotein E gene (APOE), which translates to the APOE4 isoform,
is the strongest genetic risk factor for late-onset Alzheimer disease (AD). Within the CNS …
is the strongest genetic risk factor for late-onset Alzheimer disease (AD). Within the CNS …
Apolipoprotein E in Alzheimer's disease: an update
JT Yu, L Tan, J Hardy - Annual review of neuroscience, 2014 - annualreviews.org
The vast majority of Alzheimer's disease (AD) cases are late onset (LOAD), which is
genetically complex with heritability estimates up to 80%. Apolipoprotein E (APOE) has been …
genetically complex with heritability estimates up to 80%. Apolipoprotein E (APOE) has been …
Therapeutic approaches targeting Apolipoprotein E function in Alzheimer's disease
T Williams, DR Borchelt, P Chakrabarty - Molecular neurodegeneration, 2020 - Springer
One of the primary genetic risk factors for Alzheimer's disease (AD) is the presence of the Ɛ4
allele of apolipoprotein E (APOE). APOE is a polymorphic lipoprotein that is a major …
allele of apolipoprotein E (APOE). APOE is a polymorphic lipoprotein that is a major …
[HTML][HTML] ApoE Cascade Hypothesis in the pathogenesis of Alzheimer's disease and related dementias
The ε4 allele of the apolipoprotein E gene (APOE4) is a strong genetic risk factor for
Alzheimer's disease (AD) and several other neurodegenerative conditions, including Lewy …
Alzheimer's disease (AD) and several other neurodegenerative conditions, including Lewy …
ApoE2 and Alzheimer's disease: time to take a closer look
L Wu, L Zhao - Neural regeneration research, 2016 - journals.lww.com
Alzheimer's disease (AD) is the most common form of dementia among the elderly. It
currently affects approximately 5.1 million Americans, a number predicted to triple by 2050 …
currently affects approximately 5.1 million Americans, a number predicted to triple by 2050 …
The role of apolipoprotein E in Alzheimer's disease
The ɛ4 allele of apolipoprotein E (APOE) is the major genetic risk factor for Alzheimer's
disease (AD). Although there have been numerous studies attempting to elucidate the …
disease (AD). Although there have been numerous studies attempting to elucidate the …