[HTML][HTML] Neuro-PASC is characterized by enhanced CD4+ and diminished CD8+ T cell responses to SARS-CoV-2 Nucleocapsid protein

L Visvabharathy, BA Hanson, ZS Orban… - Frontiers in …, 2023 - frontiersin.org
Introduction Many people with long COVID symptoms suffer from debilitating neurologic post-
acute sequelae of SARS-CoV-2 infection (Neuro-PASC). Although symptoms of Neuro …

[HTML][HTML] T cell responses to SARS-CoV-2 in people with and without neurologic symptoms of long COVID

L Visvabharathy, BA Hanson, ZS Orban, PH Lim… - medRxiv, 2022 - ncbi.nlm.nih.gov
Many people experiencing long COVID syndrome, or post-acute sequelae of SARS-CoV-2
infection (PASC), suffer from debilitating neurologic symptoms (Neuro-PASC). However …

[HTML][HTML] Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms

E Song, CM Bartley, RD Chow, TT Ngo, R Jiang… - Cell Reports …, 2021 - cell.com
Individuals with coronavirus disease 2019 (COVID-19) frequently develop neurological
symptoms, but the biological underpinnings of these phenomena are unknown. Through …

Neurologic sequelae of COVID-19 are determined by immunologic imprinting from previous coronaviruses

M Spatola, N Nziza, W Jung, Y Deng, D Yuan, A Dinoto… - Brain, 2023 - academic.oup.com
Abstract Coronavirus disease 2019 (COVID-19), which is caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), remains a global public health …

[HTML][HTML] Severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration: a prospective cross-sectional study

MM Etter, TA Martins, L Kulsvehagen… - Nature …, 2022 - nature.com
Growing evidence links COVID-19 with acute and long-term neurological dysfunction.
However, the pathophysiological mechanisms resulting in central nervous system …

Deep phenotyping of neurologic postacute sequelae of SARS-CoV-2 infection

Y Mina, Y Enose-Akahata, DA Hammoud… - Neurology …, 2023 - AAN Enterprises
Background and Objectives SARS-CoV-2 infection has been associated with a syndrome of
long-term neurologic sequelae that is poorly characterized. We aimed to describe and …

Plasma proteomics show altered inflammatory and mitochondrial proteins in patients with neurologic symptoms of post-acute sequelae of SARS-CoV-2 infection

BA Hanson, L Visvabharathy, ZS Orban… - Brain, Behavior, and …, 2023 - Elsevier
Persistent symptoms of COVID-19 survivors constitute long COVID syndrome, also called
post-acute sequelae of SARS-CoV-2 infection (PASC). Neurologic manifestations of PASC …

[HTML][HTML] Exploratory neuroimmune profiling identifies CNS-specific alterations in COVID-19 patients with neurological involvement

E Song, CM Bartley, RD Chow, TT Ngo, R Jiang… - bioRxiv, 2020 - ncbi.nlm.nih.gov
One third of COVID-19 patients develop significant neurological symptoms, yet SARS-CoV-2
is rarely detected in central nervous system (CNS) tissue, suggesting a potential role for …

[PDF][PDF] Neuro-COVID long-haulers exhibit broad dysfunction in T cell memory generation and responses to vaccination

L Visvabharathy, B Hanson, Z Orban, PH Lim… - MedRxiv, 2021 - medrxiv.org
The high prevalence of post-acute sequelae of SARS-CoV-2 infection (PASC) is a significant
health concern. In particular, virus-specific immunity in patients who suffer from chronic …

[HTML][HTML] Neurological manifestations of COVID-19 feature T cell exhaustion and dedifferentiated monocytes in cerebrospinal fluid

M Heming, X Li, S Räuber, AK Mausberg, AL Boersch… - Immunity, 2021 - cell.com
Patients suffering from Coronavirus disease 2019 (COVID-19) can develop neurological
sequelae, such as headache and neuroinflammatory or cerebrovascular disease. These …