Modulation of glycosylation in therapeutic proteins is a critical aspect to their development
and production. The levels of various glycan moieties greatly impact the therapeutic protein's …

Glycosylation is a critical quality attribute of most recombinant biotherapeutics.
Consequently, drug development requires careful control of glycoforms to meet bioactivity …

Highlights•Glycosylation as a Critical Quality Attribute of biopharmaceuticals.•Review of the
sixteen mathematical models for protein glycosylation that have been published since …

Glycosylated biopharmaceuticals are important in the global pharmaceutical market. Despite
the importance of their glycan structures, our limited knowledge of the glycosylation …

Regulatory bodies worldwide consider N-glycosylation to be a critical quality attribute for
immunoglobulin G (IgG) and IgG-like therapeutics. This consideration is due to the …

N-linked glycosylation is one of the most important, chemically complex and ubiquitous post-
translational modifications in all eukaryotes. The N-glycans that are covalently linked to …

Glycosylation is a critical quality attribute in biotherapeutics, impacting properties such as
protein stability, solubility, clearance rate, efficacy, immunogenicity, and safety. Due to the …

Glycans are complex, yet ubiquitous across biological systems. They are involved in diverse
essential organismal functions. Aberrant glycosylation may lead to disease development …

Kinetic models offer incomparable insight on cellular mechanisms controlling protein
glycosylation. However, their ability to reproduce site-specific glycoform distributions …

Glycosylation is one of the most complex post-translation modifications, commonly found in
many cell surface and secreted eukaryotic proteins. 1-2% of the human transcriptome …