Shared effects of DISC1 disruption and elevated WNT signaling in human cerebral organoids
P Srikanth, VN Lagomarsino, CR Muratore… - Translational …, 2018 - nature.com
The development of three-dimensional culture methods has allowed for the study of
developing cortical morphology in human cells. This provides a new tool to study the …
developing cortical morphology in human cells. This provides a new tool to study the …
Common DISC1 polymorphisms disrupt Wnt/GSK3β signaling and brain development
Summary Disrupted in Schizophrenia-1 (DISC1) is a candidate gene for psychiatric
disorders and has many roles during brain development. Common DISC1 polymorphisms …
disorders and has many roles during brain development. Common DISC1 polymorphisms …
Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1
N Dawson, M Kurihara, DM Thomson… - Translational …, 2015 - nature.com
Considerable evidence implicates DISC1 as a susceptibility gene for multiple psychiatric
diseases. DISC1 has been intensively studied at the molecular, cellular and behavioral …
diseases. DISC1 has been intensively studied at the molecular, cellular and behavioral …
DISC1-mediated dysregulation of adult hippocampal neurogenesis in rats
Adult hippocampal neurogenesis, the constitutive generation of new granule cells in the
dentate gyrus of the mature brain, is a robust model of neural development and its …
dentate gyrus of the mature brain, is a robust model of neural development and its …
[HTML][HTML] Disc1 regulates both β-catenin-mediated and noncanonical Wnt signaling during vertebrate embryogenesis
Disc1 is a schizophrenia risk gene that engages multiple signaling pathways during
neurogenesis and brain development. Using the zebrafish as a tool, we analyze the function …
neurogenesis and brain development. Using the zebrafish as a tool, we analyze the function …
DISC1 and DISC2: discovering and dissecting molecular mechanisms underlying psychiatric illness
A balanced (1; 11)(q42; q14) translocation co‐segregates with schizophrenia and major
affective disorders in a large Scottish family. The translocation breakpoint on chromosome 1 …
affective disorders in a large Scottish family. The translocation breakpoint on chromosome 1 …
DISC1 in schizophrenia: genetic mouse models and human genomic imaging
M Johnstone, PA Thomson, J Hall… - Schizophrenia …, 2011 - academic.oup.com
Schizophrenia and related disorders have a major genetic component. Several large-scale
studies have uncovered a number of possible candidate genes, but these have yet to be …
studies have uncovered a number of possible candidate genes, but these have yet to be …
DISC1 regulates the proliferation and migration of mouse neural stem/progenitor cells through Pax5, Sox2, Dll1 and Neurog2
Q Wu, W Tang, Z Luo, Y Li, Y Shu, Z Yue… - Frontiers in Cellular …, 2017 - frontiersin.org
Background: Disrupted-in-schizophrenia 1 (DISC1) regulates neurogenesis and is a genetic
risk factor for major psychiatric disorders. However, how DISC1 dysfunction affects …
risk factor for major psychiatric disorders. However, how DISC1 dysfunction affects …
Impact of DISC1 variation on neuroanatomical and neurocognitive phenotypes
Although disrupted in schizophrenia 1 (DISC1) has been implicated in many psychiatric
disorders, including schizophrenia, bipolar disorder, schizoaffective disorder and major …
disorders, including schizophrenia, bipolar disorder, schizoaffective disorder and major …
Endogenous cell type–specific disrupted in schizophrenia 1 interactomes reveal protein networks associated with neurodevelopmental disorders
B Wilkinson, OV Evgrafov, DQ Zheng, N Hartel… - Biological …, 2019 - Elsevier
Background Disrupted in schizophrenia 1 (DISC1) has been implicated in a number of
psychiatric diseases along with neurodevelopmental phenotypes such as the proliferation …
psychiatric diseases along with neurodevelopmental phenotypes such as the proliferation …