[HTML][HTML] Diversity and scale: genetic architecture of 2,068 traits in the VA Million Veteran Program
Genome-wide association studies (GWAS) have underrepresented individuals from non-
European populations, impeding progress in characterizing the genetic architecture and …
European populations, impeding progress in characterizing the genetic architecture and …
Genetic diversity turns a new PAGE in our understanding of complex traits
Genome-wide association studies (GWAS) have laid the foundation for many downstream
investigations, including the biology of complex traits, drug development, and clinical …
investigations, including the biology of complex traits, drug development, and clinical …
Importance of diversity in precision medicine: Generalizability of genetic associations across ancestry groups toward better identification of disease susceptibility …
LA Cruz, JN Cooke Bailey… - Annual review of …, 2023 - annualreviews.org
Genome-wide association studies (GWAS) revolutionized our understanding of common
genetic variation and its impact on common human disease and traits. Developed and …
genetic variation and its impact on common human disease and traits. Developed and …
Explaining additional genetic variation in complex traits
Genome-wide association studies (GWAS) have provided valuable insights into the genetic
basis of complex traits, discovering> 6000 variants associated with> 500 quantitative traits …
basis of complex traits, discovering> 6000 variants associated with> 500 quantitative traits …
A global overview of pleiotropy and genetic architecture in complex traits
K Watanabe, S Stringer, O Frei, M Umićević Mirkov… - Nature …, 2019 - nature.com
After a decade of genome-wide association studies (GWASs), fundamental questions in
human genetics, such as the extent of pleiotropy across the genome and variation in genetic …
human genetics, such as the extent of pleiotropy across the genome and variation in genetic …
Thinking about the evolution of complex traits in the era of genome-wide association studies
Many traits of interest are highly heritable and genetically complex, meaning that much of
the variation they exhibit arises from differences at numerous loci in the genome. Complex …
the variation they exhibit arises from differences at numerous loci in the genome. Complex …
Progress and promise of genome-wide association studies for human complex trait genetics
Enormous progress in mapping complex traits in humans has been made in the last 5 yr.
There has been early success for prevalent diseases with complex phenotypes. These …
There has been early success for prevalent diseases with complex phenotypes. These …
The future of genomic studies must be globally representative: perspectives from PAGE
SA Bien, GL Wojcik, CJ Hodonsky… - Annual review of …, 2019 - annualreviews.org
The past decade has seen a technological revolution in human genetics that has
empowered population-level investigations into genetic associations with phenotypes …
empowered population-level investigations into genetic associations with phenotypes …
PheWAS and beyond: the landscape of associations with medical diagnoses and clinical measures across 38,662 individuals from Geisinger
Most phenome-wide association studies (PheWASs) to date have used a small to moderate
number of SNPs for association with phenotypic data. We performed a large-scale single …
number of SNPs for association with phenotypic data. We performed a large-scale single …
Admixed populations improve power for variant discovery and portability in genome-wide association studies
Genome-wide association studies (GWAS) are primarily conducted in single-ancestry
settings. The low transferability of results has limited our understanding of human genetic …
settings. The low transferability of results has limited our understanding of human genetic …