Ageing is characterised by a physical decline in biological functioning which results in a
progressive risk of mortality with time. As a biological phenomenon, it is underpinned by the …

The process of aging results in a host of changes at the cellular and molecular levels, which
include senescence, telomere shortening, and changes in gene expression. Epigenetic …

DNA methylation (DNAm) overwrites information about multiple extrinsic factors on the
genome. Age is one of these factors. Age causes characteristic DNAm changes that are …

It is now well established that the genomic landscape of DNA methylation (DNAm) gets
altered as a function of age, a process we here call 'epigenetic drift'. The biological …

The evolutionary theories of mutation accumulation (MA) and disposable soma (DS) provide
possible explanations for the existence of human aging. To better understand the relative …

The aging phenotype is the result of a complex interaction between genetic, epigenetic and
environmental factors. Evidence suggests that epigenetic changes (ie, a set of reversible …

Aging is a major risk factor for individuals' health problems. Moreover, environmental signals
have a widespread influence on the aging process. Epigenetic modification, eg DNA …

Identifying and validating molecular targets of interventions that extend the human health
span and lifespan has been difficult, as most clinical biomarkers are not sufficiently …

Aging is arguably the most familiar yet least-well understood aspect of human biology. The
role of epigenetics in aging and age-related diseases has gained interest given recent …

Aging, which is accompanied by decreased organ function and increased disease
incidence, limits human lifespan and has attracted investigators for thousands of years. In …