Serine threonine-protein kinase-derived IW13 improves lipid metabolism via C/EBP-α/SREBP1/FAS signaling pathways in HFD-induced zebrafish in vivo larval model

A Guru, G Sudhakaran, SKR Namasivayam… - Applied Biochemistry …, 2023 - Springer
Obesity is linked to the development of major metabolic disorders such as type 2 diabetes,
cardiovascular disease, and cancer. Recent research has focused on the molecular link …

Lipid-lowering and antioxidant activity of RF13 peptide from vacuolar protein sorting-associated protein 26B (VPS26B) by modulating lipid metabolism and oxidative …

A Guru, M Velayutham, J Arockiaraj - International Journal of Peptide …, 2022 - Springer
Obesity is one of the major contributing factors responsible for the onset of various metabolic
syndrome. In obesity-related metabolic syndrome, increased oxidative stress in accumulated …

β-cells regeneration by WL15 of cysteine and glycine-rich protein 2 which reduces alloxan induced β-cell dysfunction and oxidative stress through …

A Guru, G Sudhakaran, MH Almutairi… - Molecular Biology …, 2022 - Springer
Background Pancreatic β-cells are susceptible to oxidative stress, leading to β-cell death
and dysfunction due to enhanced ROS levels and type 2 diabetes. To inhibit the β-cells …

Tryptophan-tagged peptide from serine threonine-protein kinase of Channa striatus improves antioxidant defence in L6 myotubes and attenuates caspase 3 …

PK Issac, C Lite, A Guru, M Velayutham… - Fish physiology and …, 2021 - Springer
This study reports the antioxidant property and molecular mechanism of a tryptophan-tagged
peptide derived from a teleost fish Channa striatus of serine threonine-protein kinase …

Hypolipidemic Activities of Two Pentapeptides (VIAPW and IRWWW) from Miiuy Croaker (Miichthys miiuy) Muscle on Lipid Accumulation in HepG2 Cells through …

YM Wang, X Pan, Y He, CF Chi, B Wang - Applied Sciences, 2020 - mdpi.com
In this work, the hypolipidemic activities of two pentapeptides (VIAPW and IRWWW) from
miiuy croaker (Miichthys miiuy) muscle on oleic acid (OA)-induced lipid accumulation in …

[HTML][HTML] Sturgeon protein-derived peptide KIWHHTF prevents insulin resistance via modulation of IRS-1/PI3K/AKT signaling pathways in HepG2 cells

B Yang, L Yuan, W Zhang, Q Sun, R Gao - Journal of Functional Foods, 2022 - Elsevier
KIWHHTF, a sturgeon protein-derived peptide, has been demonstrated to have potent anti-
inflammatory capacity in RAW264. 7 macrophages. However, the influence of KIWHHTF on …

Intracellular ROS scavenging and antioxidant regulation of WL15 from cysteine and glycine-rich protein 2 demonstrated in zebrafish in vivo model

A Guru, C Lite, AJ Freddy, PK Issac… - Developmental & …, 2021 - Elsevier
Antioxidant peptides are naturally present in food, especially in fishes, and are considered to
contain rich source of various bioactive compounds that are structurally heterogeneous. This …

A synthetic peptide AWRK6 ameliorates metabolic associated fatty liver disease: Involvement of lipid and glucose homeostasis

L Jin, Y Sun, Y Li, H Zhang, W Yu, Y Li, Y Xin… - Peptides, 2021 - Elsevier
Metabolic associated fatty liver disease (MAFLD) is the leading common chronic liver
disease affecting more than one-quarter of the population worldwide, but no …

The Peptide AWRK6 Alleviates Lipid Accumulation in Hepatocytes by Inhibiting miR-5100 Targeting G6PC

J Liu, Y Liu, Q Wang, L Jin, D Zhang - International Journal of Molecular …, 2023 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is the leading chronic liver disease, with a
worldwide prevalence of more than 25%, and there is no approved drug for NAFLD …

Quantitative Phosphoproteomic Analysis Reveals the Regulatory Networks of Elovl6 on Lipid and Glucose Metabolism in Zebrafish

X Wang, S Sun, X Cao, J Gao - International Journal of Molecular …, 2020 - mdpi.com
Elongation of very long-chain fatty acids protein 6 (Elovl6) has been reported to be
associated with clinical treatments of a variety of metabolic diseases. However, there is no …