The human genome contains multiple layers of information that extend beyond the genetic
sequence. In fact, identical genetics do not necessarily yield identical phenotypes as evident …

The past decade has seen an explosive growth in the utilization of single-molecule
techniques for the study of complex systems. The ability to resolve phenomena otherwise …

Next generation sequencing (NGS) is revolutionizing all fields of biological research but it
fails to extract the full range of information associated with genetic material. Optical mapping …

Optical genome mapping in nanochannels is a powerful genetic analysis method,
complementary to deoxyribonucleic acid (DNA) sequencing. The method is based on …

Optical DNA mapping has over the last decade emerged as a very powerful tool for
obtaining long range sequence information from single DNA molecules. In optical DNA …

Optical mapping of genomic DNA is of relevance for a plethora of applications such as
scaffolding for sequencing and detection of structural variations as well as identification of …

Nanofluidics enables the imaging of stretched single molecules with potential applications
for single molecule sequence mapping. Lab‐on‐a‐chip devices for single cell trapping and …

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Optical DNA mapping (ODM) allows visualization of long-range sequence information along
single DNA molecules. The data can for example be used for detecting long range structural …

Optical mapping is a fully automated single molecule system for creating ordered restriction
maps directly from genomic DNA molecules. The system has integrated components drawn …