[HTML][HTML] m5C regulator-mediated modification patterns and tumor microenvironment infiltration characterization in colorectal cancer: One step closer to precision …

B Chen, Y Xi, J Zhao, Y Hong, S Tian, X Zhai… - Frontiers in …, 2022 - frontiersin.org
Background The RNA modification 5-methylcytosine (m5C) is one of the most prevalent post-
transcriptional modifications, with increasing evidence demonstrating its extensive …

m5C regulator-mediated methylation modification phenotypes characterized by distinct tumor microenvironment immune heterogenicity in colorectal cancer

Z Chen, Q Li, Y Lin, S Lin, J Gao, S Chen - Scientific Reports, 2023 - nature.com
Abstract The RNA 5-methylcytosine (m5C) modification has been demonstrated to be an
important epigenetic regulator and to impact colorectal cancer (CRC) progression. However …

Comprehensive analysis of the prognostic value and immune infiltrates of the three-m5C signature in colon carcinoma

Q Geng, Q Wei, Z Shen, Y Zheng, L Wang… - Cancer Management …, 2021 - Taylor & Francis
Background The 5-methylcytosine (m5C) is one of the important forms of RNA post
modification, and its regulatory mechanism in tumors has received increasing attention …

Single-cell N6-methyladenosine regulator patterns guide intercellular communication of tumor microenvironment that contribute to colorectal cancer progression and …

Y Gao, H Wang, S Chen, R An, Y Chu, G Li… - Journal of Translational …, 2022 - Springer
Abstract Background N6-methyladenosine (m6A) RNA methylation plays a critical role in key
genetic events for various cancers; yet, how m6A functions within the tumor …

A novel m6A/m5C/m1A score signature to evaluate prognosis and its immunotherapy value in colon cancer patients

J Liu, M Dou, X Liu, Y Lu, W Lu - Journal of Cancer Research and Clinical …, 2023 - Springer
Background Colon cancer features strong heterogeneity and invasiveness, with high
incidence and mortality rates. Recently, RNA modifications involving m6A, m5C, and m1A …

[HTML][HTML] METTL3 inhibits antitumor immunity by targeting m6A-BHLHE41-CXCL1/CXCR2 axis to promote colorectal cancer

H Chen, Y Pan, Q Zhou, C Liang, CC Wong, Y Zhou… - Gastroenterology, 2022 - Elsevier
Background & Aims N 6-Methyladenosine (m 6 A) is the most prevalent RNA modification
and recognized as an important epitranscriptomic mechanism in colorectal cancer (CRC) …

Exploration of potential roles of m5C-related regulators in colon adenocarcinoma prognosis

Y Huang, C Huang, X Jiang, Y Yan, K Zhuang… - Frontiers in …, 2022 - frontiersin.org
Objectives: The purpose of this study was to investigate the role of 13 m5C-related
regulators in colon adenocarcinoma (COAD) and determine their prognostic value. Methods …

RNA m5C methylation orchestrates BLCA progression via macrophage reprogramming

D Yan, Y Xie, L Huang, Y Zhang, R Gu… - Journal of Cellular …, 2023 - Wiley Online Library
Recently, epigenetics showed essential roles in tumour microenvironment (TME) and
immunotherapy response, however, the functions of RNA 5‐methylcytosine (m5C) …

[HTML][HTML] m6A regulator-based methylation modification patterns characterized by distinct tumor microenvironment immune profiles in colon cancer

W Chong, L Shang, J Liu, Z Fang, F Du, H Wu, Y Liu… - Theranostics, 2021 - ncbi.nlm.nih.gov
Recent studies have highlighted the biological significance of RNA N 6-methyladenosine (m
6 A) modification in tumorigenicity and progression. However, it remains unclear whether m …

Interaction between N6-methyladenosine modification and the tumor microenvironment in colorectal cancer

J Yao, Y Song, X Yu, Z Lin - Molecular Medicine, 2023 - Springer
The incidence and mortality of colorectal cancer (CRC) are rapidly increasing worldwide.
Recently, there has been significant attention given to N6-methyladenosine (m6A), the most …