[HTML][HTML] Multimodal molecular imaging reveals tissue-based T cell activation and viral RNA persistence for up to 2 years following COVID-19

MJ Peluso, D Ryder, R Flavell, Y Wang, J Levi… - medRxiv, 2023 - ncbi.nlm.nih.gov
The etiologic mechanisms of post-acute medical morbidities and unexplained symptoms
(Long COVID) following SARS-CoV-2 infection are incompletely understood. There is …

[PDF][PDF] Longitudinal analyses reveal distinct immune response landscapes in lung and intestinal tissues from SARS-CoV-2-infected rhesus macaques

H Zheng, Y Chen, J Li, H Li, X Zhao, J Li, F Yang, Y Li… - Cell reports, 2022 - cell.com
The pathological and immune response of individuals with COVID-19 display different
dynamics in lung and intestine. Here, we depict the single-cell transcriptional atlas of …

SARS-CoV-2 mRNA vaccination–induced immunological memory in human nonlymphoid and lymphoid tissues

V Proß, A Sattler, S Lukassen, L Tóth… - The Journal of …, 2023 - Am Soc Clin Investig
Tissue-resident lymphocytes provide organ-adapted protection against invading pathogens.
Whereas their biology has been examined in great detail in various infection models, their …

Single‐cell analyses reveal SARS‐CoV‐2 interference with intrinsic immune response in the human gut

S Triana, C Metz‐Zumaran, C Ramirez… - Molecular systems …, 2021 - embopress.org
Exacerbated pro‐inflammatory immune response contributes to COVID‐19 pathology.
However, despite the mounting evidence about SARS‐CoV‐2 infecting the human gut, little …

First-in-human immunoPET imaging of COVID-19 convalescent patients using dynamic total-body PET and a CD8-targeted minibody

N Omidvari, T Jones, PM Price, AL Ferre, J Lu… - Science …, 2023 - science.org
With most of the T cells residing in the tissue, not the blood, developing noninvasive
methods for in vivo quantification of their biodistribution and kinetics is important for studying …

Longitudinal transcriptome analyses show robust T cell immunity during recovery from COVID-19

HY Zheng, M Xu, CX Yang, RR Tian, M Zhang… - Signal transduction and …, 2020 - nature.com
Understanding the processes of immune regulation in patients infected with the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for improving treatment …

Enhanced inflammation and suppressed adaptive immunity in COVID-19 with prolonged RNA shedding

X Tang, R Sun, W Ge, T Mao, L Qian, C Huang, Z Kang… - Cell Discovery, 2022 - nature.com
Little is known regarding why a subset of COVID-19 patients exhibited prolonged positivity of
SARS-CoV-2 infection. Here, we found that patients with long viral RNA course (LC) …

[HTML][HTML] Comprehensive comparison of RNA-Seq data of SARS-CoV-2, SARS-CoV and MERS-CoV infections: alternative entry routes and innate immune responses

Y Cao, X Xu, S Kitanovski, L Song, J Wang… - Frontiers in …, 2021 - frontiersin.org
Background The pathogenesis of COVID-19 emerges as complex, with multiple factors
leading to injury of different organs. Some of the studies on aspects of SARS-CoV-2 cell …

Systemic tissue and cellular disruption from SARS-CoV-2 infection revealed in COVID-19 autopsies and spatial omics tissue maps

J Park, J Foox, T Hether, D Danko, S Warren, Y Kim… - bioRxiv, 2021 - biorxiv.org
Abstract The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus has
infected over 115 million people and caused over 2.5 million deaths worldwide. Yet, the …

Reappearance of effector T cells is associated with recovery from COVID-19

I Odak, J Barros-Martins, B Bošnjak, K Stahl, S David… - …, 2020 - thelancet.com
Background Elucidating the role of T cell responses in COVID-19 is of utmost importance to
understand the clearance of SARS-CoV-2 infection. Methods 30 hospitalized COVID-19 …