Background Infants born very preterm are more likely to experience neonatal morbidities
compared to their term peers. Variations in DNA methylation (DNAm) associated with these …

Background Prenatal risk factors are related to poor health and developmental outcomes for
infants, potentially via epigenetic mechanisms. We tested associations between person …

Background Individuals born very low birthweight (VLBW) are at increased risk of impaired
cardiovascular and respiratory function in adulthood. To identify markers to predict future risk …

Background Gestational age at birth strongly predicts neonatal, adolescent and adult
morbidity and mortality through mostly unknown mechanisms. Identification of specific genes …

Risk for adverse neonatal outcome increases with declining gestational age (GA), and
changes in DNA methylation may contribute to the relationship between GA and adverse …

Background Preterm birth associates with a substantially increased risk of later
cardiovascular disease and neurodevelopmental disorders. Understanding underlying …

Fetal growth is determined by the feto-placental genome interacting with the maternal in
utero environment. Failure of this interplay leads to poor placental development and fetal …

Preterm birth is associated with dysconnectivity of structural brain networks and is a leading
cause of neurocognitive impairment in childhood. Variation in DNA methylation is …

DNA methylation (DNAm) plays a determining role in neural cell fate and provides a
molecular link between early-life stress and neuropsychiatric disease. Preterm birth is a …

A biomarker is a biological measure predictive of a normal or pathogenic process or
response. Biomarkers are often useful for making clinical decisions and determining …