Hematoma clearance is an important therapeutic target to improve outcome following
intracerebral hemorrhage (ICH). Recent studies showed that Neurokinin receptor-1 (NK1R) …

Background Pyroptosis is a programmed cell death mediated by inflammasomes. Previous
studies have reported that inhibition of neurokinin receptor 1 (NK1R) exerted …

Intracerebral hemorrhage (ICH) is characterized by poor prognosis and high mortality rates.
To date, satisfactory therapeutic approaches for ICH remain limited, so it is urgently needed …

Background Recent studies have reported that receptor-interacting protein kinase 3 (RIPK3)-
dependent necroptosis is related to the pathological process of intracerebral hemorrhage …

Background Intracerebral hemorrhage (ICH) is the most devastating stroke subtype, with a
poor prognosis and few proven treatments. Neuroinflammation is associated with ICH …

Inflammation and apoptosis are two key factors contributing to secondary brain injury after
intracerebral hemorrhage (ICH). In the present study, we explored the neuroprotective role …

Activated microglia are divided into pro-inflammatory and anti-inflammatory functional states.
In anti-inflammatory state, activated microglia contribute to phagocytosis, neural repair and …

Background and Purpose—Perihematomal edema formation and consequent cell death
contribute to the delayed brain injury evoked by intracerebral hemorrhage (ICH). We aimed …

The destruction of the blood-brain barrier (BBB) after intracerebral hemorrhage (ICH) is
associated with poor prognosis. Modulation of sphingosine 1-phosphate receptor (S1PR) …

Objective: To explore the effect of minimally invasive hematoma aspiration (MIHA) on the c-
Jun NH2-terminal kinase (JNK) signal transduction pathway after intracerebral hemorrhage …