Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis
Severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in 2002 as a highly
transmissible pathogenic human betacoronavirus. The viral spike glycoprotein (S) utilizes …
transmissible pathogenic human betacoronavirus. The viral spike glycoprotein (S) utilizes …
A 193-amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2
The coronavirus spike (S) protein mediates infection of receptor-expressing host cells and is
a critical target for antiviral neutralizing antibodies. Angiotensin-converting enzyme 2 (ACE2) …
a critical target for antiviral neutralizing antibodies. Angiotensin-converting enzyme 2 (ACE2) …
Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2
The trimeric SARS coronavirus (SARS-CoV) surface spike (S) glycoprotein consisting of
three S1-S2 heterodimers binds the cellular receptor angiotensin-converting enzyme 2 …
three S1-S2 heterodimers binds the cellular receptor angiotensin-converting enzyme 2 …
Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites
S Belouzard, VC Chu… - Proceedings of the …, 2009 - National Acad Sciences
The coronavirus spike protein (S) plays a key role in the early steps of viral infection, with the
S1 domain responsible for receptor binding and the S2 domain mediating membrane fusion …
S1 domain responsible for receptor binding and the S2 domain mediating membrane fusion …
Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding
The global outbreak of SARS in 2002-2003 was caused by the infection of a new human
coronavirus SARS-CoV. The infection of SARS-CoV is mediated mainly through the viral …
coronavirus SARS-CoV. The infection of SARS-CoV is mediated mainly through the viral …
Receptor-binding domain of SARS-CoV spike protein induces highly potent neutralizing antibodies: implication for developing subunit vaccine
The spike (S) protein of severe acute respiratory syndrome (SARS) coronavirus (CoV), a
type I transmembrane envelope glycoprotein, consists of S1 and S2 domains responsible for …
type I transmembrane envelope glycoprotein, consists of S1 and S2 domains responsible for …
Structure of SARS coronavirus spike receptor-binding domain complexed with receptor
The spike protein (S) of SARS coronavirus (SARS-CoV) attaches the virus to its cellular
receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain …
receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain …
Cellular entry of the SARS coronavirus
H Hofmann, S Pöhlmann - Trends in microbiology, 2004 - cell.com
Enveloped viruses have evolved membrane glycoproteins (GPs) that mediate entry into host
cells. These proteins are important targets for antiviral therapies and vaccines. Several …
cells. These proteins are important targets for antiviral therapies and vaccines. Several …
Structural basis of neutralization by a human anti-severe acute respiratory syndrome spike protein antibody, 80R
WC Hwang, Y Lin, E Santelli, J Sui… - Journal of Biological …, 2006 - ASBMB
Severe acute respiratory syndrome (SARS) is a newly emerged infectious disease that
caused pandemic spread in 2003. The etiological agent of SARS is a novel coronavirus …
caused pandemic spread in 2003. The etiological agent of SARS is a novel coronavirus …
Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entry
G Simmons, JD Reeves… - Proceedings of the …, 2004 - National Acad Sciences
Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is a rapidly
emerging pathogen with potentially serious consequences for public health. Here we …
emerging pathogen with potentially serious consequences for public health. Here we …