Understanding and misunderstanding randomized controlled trials

A Deaton, N Cartwright - Social science & medicine, 2018 - Elsevier
Abstract Randomized Controlled Trials (RCTs) are increasingly popular in the social
sciences, not only in medicine. We argue that the lay public, and sometimes researchers, put …

Reflections on randomized control trials

A Deaton, N Cartwright - Social science …, 2018 - durham-repository.worktribe.com
Even in our very long paper, we could not discuss all important issues about the conduct
and use of Randomized Control Trials (RCTs) in contemporary social science and medicine …

Why all randomised controlled trials produce biased results

A Krauss - Annals of medicine, 2018 - Taylor & Francis
Abstract Background: Randomised controlled trials (RCTs) are commonly viewed as the
best research method to inform public health and social policy. Usually they are thought of …

[PDF][PDF] Assessing the gold standard—lessons from the history of RCTs

LE Bothwell, JA Greene, SH Podolsky, DS Jones - N engl j med, 2016 - academia.edu
Over the past 70 years, randomized, controlled trials (RCTs) have reshaped medical
knowledge and practice. Popularized by mid-20th-century clinical researchers and …

Making trials matter: pragmatic and explanatory trials and the problem of applicability

S Treweek, M Zwarenstein - Trials, 2009 - Springer
Randomised controlled trials are the best research design for decisions about the effect of
different interventions but randomisation does not, of itself, promote the applicability of a …

Reporting and interpretation of randomized clinical trials

H Bauchner, RM Golub, PB Fontanarosa - Jama, 2019 - jamanetwork.com
High-quality randomized clinical trials (RCTs) occupy the highest position on the evidence
pyramid, either as standalone studies or as part of meta-analyses. However, the …

Are RCTs the gold standard?

N Cartwright - BioSocieties, 2007 - cambridge.org
The claims of randomized controlled trials (RCTs) to be the gold standard rest on the fact
that the ideal RCT is a deductive method: if the assumptions of the test are met, a positive …

The randomized controlled trial: gold standard, or merely standard?

J Grossman, FJ Mackenzie - Perspectives in biology and medicine, 2005 - muse.jhu.edu
The randomized controlled trial (RCT) is not a gold standard: it is a good experimental
design in some circumstances, but that's all. Potential shortcomings in the design and …

A new'Mechanistic-Practical” Framework for designing and interpreting randomized trials

PJ Karanicolas, VM Montori, PJ Devereaux… - Journal of clinical …, 2009 - Elsevier
Methodologists have traditionally categorized randomized controlled trials (RCTs) as
explanatory (representing the ideal setting) and pragmatic (representing the real-world …

Factors that can affect the external validity of randomised controlled trials

PM Rothwell - PLoS clinical trials, 2006 - journals.plos.org
Randomised controlled trials (RCTs) must be internally valid (ie, design and conduct must
eliminate the possibility of bias), but to be clinically useful, the result must also be relevant to …