ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

Alzheimer's disease (AD) is one of the most devastating neurodegenerative diseases. It has
been known for decades that the APOE ɛ 4 allele is the most significant genetic risk factor …

Abstract The Apolipoprotein E ε4 (ApoE ε4) allele, encoding ApoE4, is the strongest genetic
risk factor for late-onset Alzheimer's disease (LOAD). Emerging epidemiological evidence …

The APOE4 protein affects the primary neuropathological markers of Alzheimer's disease
(AD): amyloid plaques, neurofibrillary tangles, and gliosis. These interactions have been …

In blood, apolipoprotein E (ApoE) is a component of circulating lipoproteins and mediates
the clearance of these lipoproteins from blood by binding to ApoE receptors. Humans …

The most prevalent genetic risk factor for Alzheimer's disease (AD) is Apolipoprotein E
(ApoE), a gene located on chromosome 19 that encodes three alleles (e2, e3, and e4) that …

The APOE gene is the strongest genetic risk factor for Alzheimer's disease (AD) with the ε4
allele increasing the risk by 2-4 folds compared to the most common ε3 allele [1]. The high …

Alzheimer's disease (AD) is the most prevalent form of neurodegenerative disease, currently
affecting over 5 million Americans with projections expected to rise as the population ages …

The APOE ε4 allele remains the strongest genetic risk factor for sporadic Alzheimer's
disease and the APOE ε2 allele the strongest genetic protective factor after multiple large …

Alzheimer's disease (AD) is the leading cause of dementia affecting almost 50 million
people worldwide. The ε4 allele of Apolipoprotein E (APOE) is the strongest known genetic …