Nephron overload as a therapeutic target to maximize kidney lifespan

VA Luyckx, AD Rule, KR Tuttle, P Delanaye… - Nature Reviews …, 2022 - nature.com
Kidney lifespan is a patient-oriented outcome that provides much needed context for
understanding chronic kidney disease (CKD). Nephron endowment, age-associated decline …

[HTML][HTML] The implications of anatomical and functional changes of the aging kidney: with an emphasis on the glomeruli

RJ Glassock, AD Rule - Kidney international, 2012 - Elsevier
Aging is both a natural and inevitable biological process. With advancing age, the kidneys
undergo anatomical and physiological changes that are not only the consequences of …

Aging and the kidneys: anatomy, physiology and consequences for defining chronic kidney disease

RJ Glassock, AD Rule - Nephron, 2016 - karger.com
The varied functions of the kidneys are influenced by the complex process of aging. The
glomerular filtration rate (GFR) steadily declines with normal aging, and the progress of this …

[HTML][HTML] Aging and renal disease: old questions for new challenges

YH Chou, YM Chen - Aging and disease, 2021 - ncbi.nlm.nih.gov
Chronic kidney disease (CKD) is a growing problem among aging population, and the
number of individuals at risk of end stage renal disease is rising. Part of the reason lies in …

Kidney aging—inevitable or preventable?

D Choudhury, M Levi - Nature reviews Nephrology, 2011 - nature.com
The aging process affects all organs, including the kidneys. As part of this process,
progressive scarring and a measurable decline in renal function occur in most people over …

Prediction, progression, and outcomes of chronic kidney disease in older adults

S Anderson, JB Halter, WR Hazzard… - Journal of the …, 2009 - journals.lww.com
Chronic kidney disease is a large and growing problem among aging populations. Although
progression of chronic kidney disease to end-stage renal disease (ESRD) is a costly and …

Ageing meets kidney disease

A Ortiz, F Mattace-Raso, MJ Soler… - Clinical Kidney …, 2022 - academic.oup.com
Chronic kidney disease (CKD) is defined as abnormalities of kidney structure or function,
present for˃ 3 months, with implications for health. The most used diagnostic criteria are a …

[HTML][HTML] Healthy aging and chronic kidney disease

RA Merchant, A Vathsala - Kidney research and clinical practice, 2022 - ncbi.nlm.nih.gov
The world population is aging and the prevalence of noncommunicable diseases such as
chronic kidney disease (CKD) will increase significantly. With advances in medical treatment …

Anatomic and physiologic changes of the aging kidney

Z Karam, J Tuazon - Clinics in geriatric medicine, 2013 - geriatric.theclinics.com
Aging is a complex process driven by various molecular pathways and biochemical events
that result in significant changes in all organs. In the kidneys, aging is associated with …

Reducing kidney function decline in patients with CKD: core curriculum 2021

TK Chen, CJ Sperati, S Thavarajah… - American Journal of Kidney …, 2021 - Elsevier
An estimated 8% to 16% of the world's population has chronic kidney disease, defined by
low glomerular filtration rate or albuminuria. Progression of chronic kidney disease is …