Background Persistent pain is measured by means of self-report, the sole reliance on which
hampers diagnosis and treatment. Functional magnetic resonance imaging (fMRI) holds …

Pain often exists in the absence of observable injury; therefore, the gold standard for pain
assessment has long been self-report. Because the inability to verbally communicate can …

Identifying biomarkers that predict mental states with large effect sizes and high test-retest
reliability is a growing priority for fMRI research. We examined a well-established …

Sustained pain is a major characteristic of clinical pain disorders, but it is difficult to assess in
isolation from co-occurring cognitive and emotional features in patients. In this study, we …

Individuals are unique in terms of brain and behavior. Some are very sensitive to pain, while
others have a high tolerance. However, how inter-individual intrinsic differences in the brain …

Different pain types may be encoded in different brain circuits. Here, we examine similarities
and differences in brain processing of visceral and somatic pain. We analyze data from …

Objective Previous work suggests that the perception of pain is subjective and dependent on
individual differences in physiological, emotional, and cognitive states. Functional magnetic …

Living with unrelenting pain (chronic pain) is maladaptive and is thought to be associated
with physiological and psychological modifications, yet there is a lack of knowledge …

Characterizing a reliable, pain-related neural signature is critical for translational
applications. Many prior fMRI studies have examined acute nociceptive pain-related brain …

Pain is a subjective and complex phenomenon. Its complexity is related to its heterogeneity:
multiple component processes, including sensation, affect, and cognition, contribute to pain …