Activation of MAVS, an adaptor molecule in Rig-I-like receptor (RLR) signaling, is
indispensable for antiviral immunity, yet the molecular mechanisms modulating MAVS …

Lys63-linked polyubiquitination of RIG-I is essential in antiviral immune defense, yet the
molecular mechanism that negatively regulates this critical step is poorly understood. Here …

Innate immunity plays a pivotal role in virus infection. RIG-I senses viral RNA and initiates an
effective innate immune response for type I interferon production. To transduce RIG-I …

Background During a viral infection, the intracellular RIG-I-like receptors (RLRs) sense viral
RNA and signal through the mitochondrial antiviral signaling adaptor MAVS (also known as …

Ubiquitylation is an important mechanism for regulating innate immune responses to viral
infections. Attachment of lysine 63 (Lys63)–linked ubiquitin chains to the RNA sensor …

The signaling adaptor MAVS forms prion-like aggregates to activate an innate antiviral
immune response after viral infection. However, the molecular mechanisms that regulate …

RIG-I is a pattern recognition receptor and recognizes cytoplasmic viral double-stranded
RNA (dsRNA). Influenza A virus, hepatitis C virus, and several other pathogenic viruses are …

The innate immune system is our first line of defense against viral pathogens. Host cell
pattern recognition receptors sense viral components and initiate immune signaling …

Abstract Lysine 63 (K63)-linked ubiquitination of RIG-I plays a critical role in the activation of
type I interferon pathway, yet the molecular mechanism responsible for its deubiquitination is …

Retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs), including melanoma
differentiation-associated gene 5 (MDA5) and RIG-I, are crucial for host recognition of non …