In silico identification of natural antiviral compounds as a potential inhibitor of chikungunya virus non-structural protein 3 macrodomain

M Chaudhary, D Sehgal - Journal of Biomolecular Structure and …, 2022 - Taylor & Francis
Chikungunya Virus (CHIKV) is having a major impact on humans with potentially life-
threatening and debilitating arthritis. The lack of a specific antiviral drug against the CHIKV …

Discovery of small molecule inhibitors of chikungunya virus proteins (nsP2 and E1) using in silico approaches

N Khan, R Bhat, AK Patel, P Ray - Journal of Biomolecular …, 2021 - Taylor & Francis
Chikungunya virus (CHIKV) has emerged as a major viral threat, affecting over a million
people worldwide per year. It is a vector borne disease transmitted to the human by Ades …

Development of a theoretical model for the inhibition of nsP3 of Chikungunya virus using pyranooxazoles

D Kumar, K Kumari, A Jayaraj… - Journal of Biomolecular …, 2020 - Taylor & Francis
Chikungunya virus (CHIKV) causes Chikungunya fever (CHIKF) and till date no effective
medicine for its cure is available in market. Different research groups find various possible …

Promising inhibitors of nsp2 of CHIKV using molecular docking and temperature-dependent molecular dynamics simulations

MK Meena, D Kumar, K Kumari… - Journal of …, 2022 - Taylor & Francis
Infection due to the Chikungunya virus (CHIKV) has taken the life of lots of people; and
researchers are working to find the vaccine or promisng drug candidates against this viral …

Structure based virtual screening, 3D-QSAR, molecular dynamics and ADMET studies for selection of natural inhibitors against structural and non-structural targets of …

J Vora, S Patel, S Sinha, S Sharma… - Journal of …, 2018 - Taylor & Francis
The transmission of mosquito-borne Chikungunya virus (CHIKV) has large epidemics
worldwide. Till date, there are neither anti-viral drugs nor vaccines available for the …

In-silico and biophysical investigation of biomolecular interaction between naringin and nsP2 of the chikungunya virus

PK Tripathi, J Singh, N Gaurav, DK Garg… - International Journal of …, 2020 - Elsevier
Chikungunya virus; the pathogen for chikungunya febrile and arthritic disease, having 11.8
kb positive-sense RNA genome encodes polyproteins for structural and non-structural …

Towards the identification of novel phytochemical leads as macrodomain inhibitors of chikungunya virus using molecular docking approach

S Vijayasri, W Hopper - Journal of Applied Pharmaceutical Science, 2017 - japsonline.com
The outbreak of Chikungunya fever worldwide has raised a threat to human health and an
economic burden on the affected countries. Currently, there is no cure for Chikungunya. The …

[HTML][HTML] In silico analysis of natural compounds targeting structural and nonstructural proteins of chikungunya virus

J Jain, A Kumari, P Somvanshi, A Grover, S Pai… - …, 2017 - ncbi.nlm.nih.gov
Background: Chikungunya fever presents as a high-grade fever during its acute febrile
phase and can be prolonged for months as chronic arthritis in affected individuals. Currently …

In silico studies revealed interaction mechanisms of benzylidene–acrylohydrazide derivatives and nsP2 CHIKV

LS Muniz, SS da Rocha Pita - New Journal of Chemistry, 2022 - pubs.rsc.org
The Chikungunya virus (CHIKV, Togaviridae family, Alphavirus genus) represents an
emerging public health problem worldwide because it causes high morbidity and mortality …

Analysis of inhibitor binding combined with reactivity studies to discover the potentially inhibiting phytochemicals targeting Chikungunya viral replication

N Rasool, A Bakht, W Hussain - Current Drug Discovery …, 2021 - ingentaconnect.com
Background: Chikungunya fever is a challenging threat to human health in various parts of
the world nowadays. Many attempts have been made for developing an effective drug …