Potential use of bitter melon (Momordica charantia) derived compounds as antidiabetics: in silico and in vivo studies

OO Elekofehinti, EO Ariyo, MO Akinjiyan, OS Olayeriju… - Pathophysiology, 2018 - Elsevier
Momordica charantia (bitter lemon) belongs to the cucurbitaceae family which has been
extensively used in traditional medicines for the cure of various ailments such as cancer and …

Cucurbitane-type compounds from Momordica charantia: Isolation, in vitro antidiabetic, anti-inflammatory activities and in silico modeling approaches

SR Shivanagoudra, WH Perera, JL Perez, G Athrey… - Bioorganic …, 2019 - Elsevier
Momordica charantia L., commonly known as bitter melon, belongs to the Cucurbitaceae
family. Various in vitro and in vivo studies have indicated that extracts of bitter melons have …

Investigating the multitargeted anti-diabetic potential of cucurbitane-type triterpenoid from Momordica charantia: an LC-MS, docking-based MM\GBSA and MD …

SO Famuyiwa, S Ahmad, KO Olufolabo… - Journal of …, 2023 - Taylor & Francis
Type 2 diabetes accounts for the largest percentage of all diabetic cases worldwide.
Cucurbitane-type triterpenes are mainly found in Momordica charantia and possess …

In vitro and in silico elucidation of antidiabetic and anti-inflammatory activities of bioactive compounds from Momordica charantia L.

SR Shivanagoudra, WH Perera, JL Perez… - Bioorganic & Medicinal …, 2019 - Elsevier
Bitter melon (Momordica charantia) has been used to manage diabetes and related
conditions in various parts of the world. In the present study, ten compounds were isolated …

[HTML][HTML] Anti-inflammatory, antidiabetic properties and in silico modeling of cucurbitane-type triterpene glycosides from fruits of an Indian cultivar of Momordica …

WH Perera, SR Shivanagoudra, JL Pérez, DM Kim… - Molecules, 2021 - mdpi.com
Diabetes mellitus is a chronic disease and one of the fastest-growing health challenges of
the last decades. Studies have shown that chronic low-grade inflammation and activation of …

[HTML][HTML] The Effects of Momordica charantia on Type 2 Diabetes Mellitus and Alzheimer's Disease

E Richter, T Geetha, D Burnett, TL Broderick… - International Journal of …, 2023 - mdpi.com
T2DM is a complex metabolic disorder characterized by hyperglycemia and glucose
intolerance. It is recognized as one of the most common metabolic disorders and its …

Flavonoid-rich extract of Chromolaena odorata modulate circulating GLP-1 in Wistar rats: computational evaluation of TGR5 involvement

OI Omotuyi, O Nash, OK Inyang, J Ogidigo, O Enejoh… - 3 Biotech, 2018 - Springer
Chromolaena odorata is a major bio-resource in folkloric treatment of diabetes. In the
present study, its anti-diabetic component and underlying mechanism were investigated. A …

[PDF][PDF] In silico study of the active compounds in bitter melon (Momordica charantia L) as antidiabetic medication

R Ruswanto, R Mardianingrum, T Lestari… - …, 2018 - pdfs.semanticscholar.org
Antidiabetic drugs are widely available in the market, but most medications have strong side
effects that may cause toxicity. Therefore, a search for new drug compounds that are more …

[PDF][PDF] An evaluation of anti-diabetic and anti-lipidemic properties of Momordica charantia (Bitter Melon) fruit extract in experimentally induced diabetes

I Mohammady, S Elattar, S Mohammed, M Ewais - Life Sci J, 2012 - lifesciencesite.com
Aim: Momordica charantia is reported to possess hypoglycemic activity. This study aims at
investigating the effect of Momordica charantia extract on glucose tolerance and some …

[PDF][PDF] A detailed review on the phytochemical profiles and anti-diabetic mechanisms of Momordica charantia

SF Oyelere, OH Ajayi, TE Ayoade, GBS Pereira… - Heliyon, 2022 - cell.com
Diabetes mellitus is the most well-known endocrine dilemma suffered by hundreds of million
people globally, with an annual mortality of more than one million people. This high mortality …