Microstructural and compositional changes that occur due to aging, pathological conditions,
or pharmacological treatments alter cortical bone fracture resistance. However, the relative …

The increased risk for fracture with age is associated not only with reduced bone mass but
also with impaired bone quality. At the microscale, bone quality is related to porosity …

The recent reports of atypical femoral fracture (AFF) and its possible association with
prolonged bisphosphonate (BP) use highlighted the importance of a thorough …

Microstructural features including osteons and cement lines are considered to play an
important role in determining the crack growth behaviour in cortical bone. This study aims to …

Bone is similar to fiber-reinforced composite materials made up of distinct phases such as
osteons (fiber), interstitial bone (matrix), and cement lines (matrix-fiber interface) …

Bulk properties of cortical bone have been well characterized experimentally, and potent
toughening mechanisms, eg, crack deflections, have been identified at the microscale …

The recent studies have shown that long-term bisphosphonate use may result in a number
of mechanical alterations in the bone tissue including a reduction in compositional …

Bone encompasses a complex arrangement of materials at different length scales, which
endows it with a range of mechanical, chemical, and biological capabilities. Changes in the …

The microstructure of cortical bone is key for the tissue's high toughness and strength and
efficient toughening mechanisms have been identified at the microscale, for example when …

Evaluating the mechanical response of bone under high loading rates is crucial to
understanding fractures in traumatic accidents or falls. In the current study, a computational …