Genetic analyses identify widespread sex-differential participation bias

N Pirastu, M Cordioli, P Nandakumar, G Mignogna… - Nature Genetics, 2021 - nature.com
Genetic association results are often interpreted with the assumption that study participation
does not affect downstream analyses. Understanding the genetic basis of participation bias …

[HTML][HTML] Studying the genetics of participation using footprints left on the ascertained genotypes

S Benonisdottir, A Kong - Nature Genetics, 2023 - nature.com
The trait of participating in a genetic study probably has a genetic component. Identifying this
component is difficult as we cannot compare genetic information of participants with …

Don't ignore genetic data from minority populations

C Ben-Eghan, R Sun, JS Hleap, A Diaz-Papkovich… - Nature, 2020 - nature.com
Don’t ignore genetic data from minority populations Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the best …

[HTML][HTML] Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects

LJ Howe, MG Nivard, TT Morris, AF Hansen… - Nature …, 2022 - nature.com
Estimates from genome-wide association studies (GWAS) of unrelated individuals capture
effects of inherited variation (direct effects), demography (population stratification …

[HTML][HTML] Participation bias in the UK Biobank distorts genetic associations and downstream analyses

T Schoeler, D Speed, E Porcu, N Pirastu… - Nature Human …, 2023 - nature.com
While volunteer-based studies such as the UK Biobank have become the cornerstone of
genetic epidemiology, the participating individuals are rarely representative of their target …

Genetic evidence of assortative mating in humans

MR Robinson, A Kleinman, M Graff… - Nature Human …, 2017 - nature.com
In human populations, assortative mating is almost universally positive, with similarities
between partners for quantitative phenotypes–, common disease risk,,–, behaviour,, social …

[PDF][PDF] Amplification is the primary mode of gene-by-sex interaction in complex human traits

C Zhu, MJ Ming, JM Cole, MD Edge, M Kirkpatrick… - Cell Genomics, 2023 - cell.com
Sex differences in complex traits are suspected to be in part due to widespread gene-by-sex
interactions (GxSex), but empirical evidence has been elusive. Here, we infer the mixture of …

Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior

A Ganna, KJH Verweij, MG Nivard, R Maier, R Wedow… - Science, 2019 - science.org
INTRODUCTION Across human societies and in both sexes, some 2 to 10% of individuals
report engaging in sex with same-sex partners, either exclusively or in addition to sex with …

Sex differences in genetic architecture in the UK Biobank

E Bernabeu, O Canela-Xandri, K Rawlik, A Talenti… - Nature …, 2021 - nature.com
Males and females present differences in complex traits and in the risk of a wide array of
diseases. Genotype by sex (GxS) interactions are thought to account for some of these …

[HTML][HTML] Evidence for sex-specific genetic architectures across a spectrum of human complex traits

K Rawlik, O Canela-Xandri, A Tenesa - Genome biology, 2016 - Springer
Background Sex differences are a common feature of human traits; however, the role sex
determination plays in human genetic variation remains unclear. The presence of gene-by …