[HTML][HTML] The amyloid-β pathway in Alzheimer's disease

H Hampel, J Hardy, K Blennow, C Chen, G Perry… - Molecular …, 2021 - nature.com
Breakthroughs in molecular medicine have positioned the amyloid-β (Aβ) pathway at the
center of Alzheimer's disease (AD) pathophysiology. While the detailed molecular …

Emerging pathways driving early synaptic pathology in Alzheimer's disease

CA Briggs, S Chakroborty, GE Stutzmann - Biochemical and biophysical …, 2017 - Elsevier
The current state of the AD research field is highly dynamic is some respects, while
seemingly stagnant in others. Regarding the former, our current lack of understanding of …

[HTML][HTML] Challenges for Alzheimer's disease therapy: insights from novel mechanisms beyond memory defects

RL Frozza, MV Lourenco, FG De Felice - Frontiers in neuroscience, 2018 - frontiersin.org
Alzheimer's disease (AD), the most common form of dementia in late life, will become even
more prevalent by midcentury, constituting a major global health concern with huge …

Biological markers of amyloid β-related mechanisms in Alzheimer's disease

H Hampel, Y Shen, DM Walsh, P Aisen, LM Shaw… - Experimental …, 2010 - Elsevier
Recent research progress has given detailed knowledge on the molecular pathogenesis of
Alzheimer's disease (AD), which has been translated into an intense, ongoing development …

Aspects of β-amyloid as a biomarker for Alzheimer's disease

U Andreasson, E Portelius, ME Andersson, K Blennow… - 2007 - Taylor & Francis
Alzheimer's disease is an age-related neurodegenerative disorder that results in
progressive cognitive impairment and death. The accumulation of β-amyloid (Aβ) in specific …

[HTML][HTML] An insight into cellular and molecular mechanisms underlying the pathogenesis of neurodegeneration in Alzheimer's disease

Y Ratan, A Rajput, S Maleysm, A Pareek, V Jain… - Biomedicines, 2023 - mdpi.com
Alzheimer's disease (AD) is the most prominent neurodegenerative disorder in the aging
population. It is characterized by cognitive decline, gradual neurodegeneration, and the …

[HTML][HTML] Current progress, challenges and future prospects of diagnostic and therapeutic interventions in Alzheimer's disease

K Rajasekhar, T Govindaraju - RSC advances, 2018 - pubs.rsc.org
Alzheimer's disease (AD) is the most prevalent, progressive and multifaceted
neurodegenerative disorder associated with cognition, memory and behavioural …

Amyloid β-interacting partners in Alzheimer's disease: from accomplices to possible therapeutic targets

SH Han, JC Park, I Mook-Jung - Progress in neurobiology, 2016 - Elsevier
Alzheimer's disease (AD) is one of the most devastating neurodegenerative diseases in
modern society because of insurmountable difficulties in early diagnosis and lack of …

[HTML][HTML] Amyloid β-based therapy for Alzheimer's disease: Challenges, successes and future

Y Zhang, H Chen, R Li, K Sterling… - Signal transduction and …, 2023 - nature.com
Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer's disease
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …

A systemic view of Alzheimer disease—insights from amyloid-β metabolism beyond the brain

J Wang, BJ Gu, CL Masters, YJ Wang - Nature reviews neurology, 2017 - nature.com
Alzheimer disease (AD) is the most common type of dementia, and is currently incurable;
existing treatments for AD produce only a modest amelioration of symptoms. Research into …