[HTML][HTML] COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice

J Zheng, LYR Wong, K Li, AK Verma, ME Ortiz… - Nature, 2021 - nature.com
The ongoing coronavirus disease 2019 (COVID-19) pandemic is associated with substantial
morbidity and mortality. Although much has been learned in the first few months of the …

[HTML][HTML] The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice

L Bao, W Deng, B Huang, H Gao, J Liu, L Ren, Q Wei… - Nature, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus
disease 2019 (COVID-19), which has become a public health emergency of international …

[HTML][HTML] A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures

KH Dinnon III, SR Leist, A Schäfer, CE Edwards… - Nature, 2020 - nature.com
Coronaviruses are prone to transmission to new host species, as recently demonstrated by
the spread to humans of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

[HTML][HTML] Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19

LYR Wong, J Zheng, K Wilhelmsen, K Li, ME Ortiz… - Nature, 2022 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) is especially severe in aged populations.
Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are …

Administration of aerosolized SARS-CoV-2 to K18-hACE2 mice uncouples respiratory infection from fatal neuroinvasion

V Fumagalli, M Ravà, D Marotta, P Di Lucia… - Science …, 2021 - science.org
The development of a tractable small animal model faithfully reproducing human
coronavirus disease 2019 pathogenesis would arguably meet a pressing need in …

[HTML][HTML] Inflammasome activation in infected macrophages drives COVID-19 pathology

E Sefik, R Qu, C Junqueira, E Kaffe, H Mirza, J Zhao… - Nature, 2022 - nature.com
Severe COVID-19 is characterized by persistent lung inflammation, inflammatory cytokine
production, viral RNA and a sustained interferon (IFN) response, all of which are …

Mechanisms of SARS-CoV-2-associated anosmia

T Tsukahara, DH Brann, SR Datta - Physiological Reviews, 2023 - journals.physiology.org
Anosmia, the loss of the sense of smell, is one of the main neurological manifestations of
COVID-19. Although the SARS-CoV-2 virus targets the nasal olfactory epithelium, current …

[HTML][HTML] Neuroinvasion and anosmia are independent phenomena upon infection with SARS-CoV-2 and its variants

GD de Melo, V Perraud, F Alvarez… - Nature …, 2023 - nature.com
Anosmia was identified as a hallmark of COVID-19 early in the pandemic, however, with the
emergence of variants of concern, the clinical profile induced by SARS-CoV-2 infection has …

[HTML][HTML] SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function

ES Winkler, AL Bailey, NM Kafai, S Nair… - Nature …, 2020 - nature.com
Although animal models have been evaluated for severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection, none have fully recapitulated the lung disease …

[HTML][HTML] Structural basis of receptor recognition by SARS-CoV-2

J Shang, G Ye, K Shi, Y Wan, C Luo, H Aihara, Q Geng… - Nature, 2020 - nature.com
A novel severe acute respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2) recently
emerged and is rapidly spreading in humans, causing COVID-19 1, 2. A key to tackling this …