Background Emerging evidence indicates that inflammasome-induced inflammation plays a
crucial role in the pathogenesis of Parkinson's disease (PD). Several proteins including α …

Background Alpha-synuclein and inflammatory pathology are evident in Parkinson's disease
(PD) but, their link to disease pathogenesis needs further elucidation. Objectives To explore …

Parkinson's disease (PD) is the second most common neurodegenerative disease, with two
main pathological features: misfolded α-synuclein protein accumulation and …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor and non-
motor symptoms and loss of dopaminergic neurons of the substantia nigra. Inflammation and …

According to emerging studies, the excessive activation of microglia and the subsequent
release of pro-inflammatory cytokines play important roles in the pathogenesis and …

Parkinson's disease (PD) is a common neurodegenerative disorder caused by the loss of
dopamine neurons in the substantia nigra and the formation of Lewy bodies, which are …

Mechanism by which α-synuclein affects the progression of Parkinson's disease through
Pyrin Domain Containing Protein 3 (NLRP3) was explored. Peripheral blood plasma of 40 …

The etiology and pathogenesis of Parkinson's disease (PD) are complicated and have not
been fully elucidated, but an important association has been identified between …

Background Parkinson's disease (PD) is characterized by degeneration of dopaminergic
neurons in the substantia nigra pars compacta (SNpc), accompanied by accumulation of α …

Abstract Background α-Synuclein (α-Syn), a pathological hallmark of Parkinson's disease
(PD), has been recognized to induce the production of interleukin-1β in a process that …