Background Genome-wide association studies (GWAS) have identified> 200 loci associated
with breast cancer risk. The majority of candidate causal variants are in non-coding regions …

Background Most cancer risk-associated single nucleotide polymorphisms (SNPs) identified
by genome-wide association studies (GWAS) are noncoding and it is challenging to assess …

The majority of cancers are driven by multiple genetic alterations, but how these changes
collaborate during tumorigenesis remains largely unknown. To gain mechanistic insights …

Introduction Genes contain multiple promoters that can drive the expression of various
transcript isoforms. Although transcript isoforms from the same gene could have diverse and …

CRISPR/Cas9 has emerged as a powerful new tool to systematically probe gene function.
We compared the performance of CRISPR to RNAi-based loss-of-function screens for the …

Genome-wide association studies have identified breast cancer risk variants in over 150
genomic regions, but the mechanisms underlying risk remain largely unknown. These …

Background Genome-wide association studies have identified 196 high confidence
independent signals associated with breast cancer susceptibility. Variants within these …

Background Genome-scale pooled CRISPR screens are powerful tools for identifying
genetic dependencies across varied cellular processes. The vast majority of CRISPR …

Genome-wide association studies coupled with large-scale replication and fine-scale
mapping studies have identified more than 150 genomic regions that are associated with …

Abstract Background Long noncoding RNAs (lncRNAs) have surpassed the number of
protein-coding genes, yet the majority have no known function. We previously discovered …