Ischemic preconditioning in humans: models, mediators, and clinical relevance

F Tomai, F Crea, L Chiariello, PA Gioffrè - Circulation, 1999 - Am Heart Assoc
Ischemic preconditioning, a powerful form of endogenous protection against myocardial
infarction, has been demonstrated in several animal species and, recently, in isolated …

Signal transduction in ischemic preconditioning

JM Downey, MV Cohen - Analytical and Quantitative Cardiology, 1997 - Springer
Ischemic preconditioning is a phenomenon in which exposure of the heart to a brief period
of ischemia causes it to quickly adapt itself to become resistant to infarction from a …

Signal transduction of ischemic preconditioning

R Schulz, MV Cohen, M Behrends… - Cardiovascular …, 2001 - academic.oup.com
1. Ischemic preconditioning and its endpoints morphological protection, while on the other
hand caution should be used when extrapolating findings from short-Brief episodes of …

Ischemic preconditioning: nearly two decades of research. A comprehensive review

A Eisen, EZ Fisman, M Rubenfire, D Freimark… - Atherosclerosis, 2004 - Elsevier
The phenomenon of “ischemic preconditioning” has been recognized for almost two
decades. In experimental animals and humans, a brief period of ischemia has been shown …

Prodromal angina limits infarct size: a role for ischemic preconditioning

F Ottani, M Galvani, D Ferrini, F Sorbello, P Limonetti… - Circulation, 1995 - Am Heart Assoc
Background In the experimental setting, it has been demonstrated that preconditioning
myocardium before prolonged occlusion with brief ischemic episodes affords substantial …

Does ischemic preconditioning occur in patients?

RA Kloner, D Yellon - Journal of the American College of Cardiology, 1994 - Elsevier
Ischemic preconditioning offers powerful protection from ischemie necrosis in a wide range
of animal species, but does it occur in humans? Support for preconditioning in humans …

Ischemic preconditioning and preinfarction angina in the clinical arena

SH Rezkalla, RA Kloner - Nature clinical practice Cardiovascular …, 2004 - nature.com
In animals, brief episodes of ischemia before a total coronary occlusion protect the heart and
result in a smaller myocardial infarct size. In humans, episodes of angina before acute …

Preconditioning the myocardium: from cellular physiology to clinical cardiology

DM Yellon, JM Downey - Physiological reviews, 2003 - journals.physiology.org
Yellon, Derek M., and James M. Downey. Preconditioning the Myocardium: From Cellular
Physiology to Clinical Cardiology. Physiol Rev 83: 1113-1151, 2003; 10.1152/physrev …

The preconditioning phenomenon: a tool for the scientist or a clinical reality?

DM Yellon, A Dana - Circulation research, 2000 - Am Heart Assoc
The possibility that an innate mechanism of myocardial protection might be inducible in the
human heart has generated considerable excitement and enthusiastic research. The …

Pronounced antiarrhythmic effects of ischemic preconditioning.

J Parratt, A Vegh - Cardioscience, 1994 - europepmc.org
Brief periods of ischemia, induced either by complete coronary artery occlusion or by rapid
ventricular pacing, greatly reduce the severity of those live-threatening ventricular …