SARS-CoV-2 infection is benign in most individuals but, in around 10% of cases, it triggers
hypoxaemic COVID-19 pneumonia, which leads to critical illness in around 3% of cases …

Host-mediated lung inflammation is present, and drives mortality, in the critical illness
caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with …

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic
variation influences the development of illness requiring critical care or hospitalization,–after …

Autosomal inborn errors of type I IFN immunity and autoantibodies against these cytokines
underlie at least 10% of critical COVID-19 pneumonia cases. We report very rare …

SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection is silent or benign
in most infected individuals, but causes hypoxemic COVID-19 pneumonia in about 10% of …

To the Editor—As the COVID Human Genetic Effort consortium (https://www. covidhge.
com/), we have studied genetic and immunological determinants of life-threatening COVID …

Although infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
pleiotropic and systemic effects in some individuals,–, many others experience milder …

INTRODUCTION Clinical outcomes of human severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection range from silent infection to lethal coronavirus …

A long-term perspective on immunity to COVID Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the best …

Investigating the role of host genetic factors in COVID-19 severity and susceptibility can
inform our understanding of the underlying biological mechanisms that influence adverse …