The identities of different cells and tissues in multicellular organisms are determined by
tightly controlled transcriptional programs that enable accurate gene expression. The …

Early studies established that transcription initiates within an approximately 50bp DNA
segment capable of nucleating the assembly of RNA polymerase II (Pol II) and associated …

Abstract RNA polymerase II (Pol II) core promoters are specialized DNA sequences at
transcription start sites of protein-coding and non-coding genes that support the assembly of …

The RNA polymerase II core promoter is generally defined to be the sequence that directs
the initiation of transcription. This simple definition belies a diverse and complex …

The identification and characterization of mammalian core promoters and transcription start
sites is a prerequisite to understanding how RNA polymerase II transcription is controlled …

The RNA polymerase II core promoter is a structurally and functionally diverse
transcriptional regulatory element. There are two main strategies for transcription initiation …

Core promoters are minimal regions sufficient to direct accurate initiation of transcription and
are crucial for regulation of gene expression. They are highly diverse in terms of associated …

Transcription initiation is a key regulatory step in the control of gene expression. Formation
of a preinitiation complex at the right time and at the right promoter is a prerequisite to …

The RNA polymerase II core promoter is sometimes referred to as the gateway to
transcription. The core promoter is generally defined to be the stretch of DNA that directs the …

Gene transcription occurs via a cycle of linked events, including initiation, promoter-proximal
pausing, and elongation of RNA polymerase II (Pol II). A key question is how transcriptional …