Recent scientific studies have advanced the notion of chronic inflammation as a major risk factor underlying aging and age-related diseases. In this review, low-grade, unresolved …
HY Chung, DH Kim, EK Lee, KW Chung… - Aging and …, 2019 - ncbi.nlm.nih.gov
Age-associated chronic inflammation is characterized by unresolved and uncontrolled inflammation with multivariable low-grade, chronic and systemic responses that exacerbate …
IM Rea, DS Gibson, V McGilligan… - Frontiers in …, 2018 - frontiersin.org
Cytokine dysregulation is believed to play a key role in the remodeling of the immune system at older age, with evidence pointing to an inability to fine-control systemic …
Background Recently, the hallmarks of aging were updated to include dysbiosis, disabled macroautophagy, and chronic inflammation. In particular, the low-grade chronic …
S Xia, X Zhang, S Zheng, R Khanabdali… - Journal of …, 2016 - Wiley Online Library
Inflamm‐aging is a challenging and promising new branch of aging‐related research fields that includes areas such as immunosenescence. Increasing evidence indicates that inflamm …
Abstract The National Institutes of Health (NIH) Geroscience Interest Group (GSIG) sponsored workshop, The Role of Inflammation in Age-Related Disease, was held …
Acute inflammation is a physiological response to injury or infection, with a cascade of steps that ultimately lead to the recruitment of immune cells to clear invading pathogens and heal …
MC Bachmann, S Bellalta, R Basoalto… - Frontiers in …, 2020 - frontiersin.org
The aging process is driven by multiple mechanisms that lead to changes in energy production, oxidative stress, homeostatic dysregulation and eventually to loss of functionality …
G Pawelec, D Goldeck, E Derhovanessian - Current opinion in immunology, 2014 - Elsevier
Highlights•Elderly people commonly show signs of low level systemic inflammation.•Causes include presence of senescent cells, chronic infections and obesity.•Systemic inflammation …