[HTML][HTML] Cognitive impairment and type 2 diabetes mellitus: Focus of SGLT2 inhibitors treatment

MR Rizzo, I Di Meo, R Polito, MC Auriemma… - Pharmacological …, 2022 - Elsevier
Gliflozins are a novel class of oral anti-diabetic drugs, acting as inhibitors of sodium-glucose
co-transporters (SGLTs) through the proximal convoluted tubules (PCT) and intestinal …

Neuroprotective effect of SGLT2 inhibitors

A Pawlos, M Broncel, E Woźniak, P Gorzelak-Pabiś - Molecules, 2021 - mdpi.com
Patients with diabetes are at higher risk of cardiovascular diseases and cognitive
impairment. SGLT2 inhibitors (Empagliflozin, Canagliflozin, Dapagliflozin, Ertugliflozin …

Perspective of SGLT2 inhibition in treatment of conditions connected to neuronal loss: focus on Alzheimer's disease and ischemia-related brain injury

M Wiciński, E Wódkiewicz, K Górski, M Walczak… - Pharmaceuticals, 2020 - mdpi.com
Sodium-glucose co-transporter 2 inhibitors (SGLT2i) are oral anti-hyperglycemic agents
approved for the treatment of type 2 diabetes mellitus. Some reports suggest their presence …

Unlocking the full potential of SGLT2 inhibitors: expanding applications beyond glycemic control

ME Youssef, G Yahya, MS Popoviciu, S Cavalu… - International Journal of …, 2023 - mdpi.com
The number of diabetic patients has risen dramatically in recent decades, owing mostly to
the rising incidence of type 2 diabetes mellitus (T2DM). Several oral antidiabetic …

SGLT2 inhibitors: an evidence-based update on cardiovascular implications

I Forzano, S Wilson, A Lombardi… - Expert Opinion on …, 2023 - Taylor & Francis
ABSTRACT Introduction Sodium Glucose co-Transporter 2 (SGLT2) inhibitors (also known
as 'gliflozins') represent a cornerstone to treat diabetes mellitus. Moreover, recent …

Cardiovascular benefits from gliflozins: effects on endothelial function

T Salvatore, A Caturano, R Galiero, A Di Martino… - Biomedicines, 2021 - mdpi.com
Type 2 diabetes mellitus (T2DM) is a known independent risk factor for atherosclerotic
cardiovascular disease (CVD) and solid epidemiological evidence points to heart failure …

SGLT2 inhibitors and risk of stroke in patients with type 2 diabetes: a systematic review and meta‐analysis

M Guo, J Ding, J Li, J Wang, T Zhang… - Diabetes, Obesity …, 2018 - Wiley Online Library
The effects of sodium‐glucose cotransporter 2 (SGLT2) inhibitors on risk of stroke have not
been conclusively established. Therefore, we conducted a meta‐analysis to evaluate the …

Cardioprotection conferred by sodium-glucose cotransporter 2 inhibitors: a renal proximal tubule perspective

D Silva dos Santos, JZ Polidoro… - … of Physiology-Cell …, 2020 - journals.physiology.org
Sodium-glucose cotransporter 2 (SGLT2) inhibitors, also known as gliflozins, improve
glycemia by suppressing glucose reuptake in the renal proximal tubule. Currently, SGLT2 …

Sodium-glucose cotransporter 2 inhibitors mechanisms of action: a review

JI Fonseca-Correa, R Correa-Rotter - Frontiers in Medicine, 2021 - frontiersin.org
Sodium-Glucose Cotransporter 2 inhibitors (SGLT2i), or gliflozins, are a group of antidiabetic
drugs that have shown improvement in renal and cardiovascular outcomes in patients with …

Pharmacological aspects of the safety of gliflozins

JL Faillie - Pharmacological research, 2017 - Elsevier
Abstract Sodium-glucose transporter 2 (SGLT2) inhibitors, also known as gliflozins, are a
new class of orally active drugs used in the management of type 2 diabetes. By inhibiting the …