NAD+ metabolism and its roles in cellular processes during ageing

AJ Covarrubias, R Perrone, A Grozio… - Nature reviews Molecular …, 2021 - nature.com
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme for redox reactions, making it
central to energy metabolism. NAD+ is also an essential cofactor for non-redox NAD+ …

[HTML][HTML] The balance between NAD+ biosynthesis and consumption in ageing

Ø Strømland, J Diab, E Ferrario, LJ Sverkeli… - Mechanisms of Ageing …, 2021 - Elsevier
Nicotinamide adenine dinucleotide (NAD+) is a vital coenzyme in redox reactions. NAD+ is
also important in cellular signalling as it is consumed by PARPs, SARM1, sirtuins and CD38 …

NAD+ in aging: molecular mechanisms and translational implications

EF Fang, S Lautrup, Y Hou, TG Demarest… - Trends in molecular …, 2017 - cell.com
The coenzyme NAD+ is critical in cellular bioenergetics and adaptive stress responses. Its
depletion has emerged as a fundamental feature of aging that may predispose to a wide …

[HTML][HTML] Therapeutic potential of boosting NAD+ in aging and age-related diseases

Y Aman, Y Qiu, J Tao, EF Fang - Translational Medicine of Aging, 2018 - Elsevier
Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor in all living cells that is
involved in fundamental biological processes. NAD+ depletion has been associated with …

Roles of NAD+ in Health and Aging

S Lautrup, Y Hou, EF Fang… - Cold Spring …, 2024 - perspectivesinmedicine.cshlp.org
NAD+, the essential metabolite involved in multiple reactions such as the regulation of
cellular metabolism, energy production, DNA repair, mitophagy and autophagy …

Regulation of NAD+ metabolism in aging and disease

X Chu, RP Raju - Metabolism, 2022 - Elsevier
More than a century after discovering NAD+, information is still evolving on the role of this
molecule in health and diseases. The biological functions of NAD+ and NAD+ precursors …

NAD+ and sirtuins in aging and disease

S Imai, L Guarente - Trends in cell biology, 2014 - cell.com
Nicotinamide adenine dinucleotide (NAD+) is a classical coenzyme mediating many redox
reactions. NAD+ also plays an important role in the regulation of NAD+-consuming …

NAD+ in aging, metabolism, and neurodegeneration

E Verdin - Science, 2015 - science.org
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in all living cells. It serves
both as a critical coenzyme for enzymes that fuel reduction-oxidation reactions, carrying …

[HTML][HTML] NAD+ biosynthesis, aging, and disease

S Johnson, S Imai - F1000Research, 2018 - ncbi.nlm.nih.gov
Nicotinamide adenine dinucleotide (NAD+) biosynthesis and its regulation have recently
been attracting markedly increasing interest. Aging is marked by a systemic decrease in …

Why NAD+ declines during aging: it's destroyed

MB Schultz, DA Sinclair - Cell metabolism, 2016 - cell.com
Why NAD+ Declines during Aging: It’s Destroyed: Cell Metabolism Skip to Main Content
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