Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19

F D'Agnillo, KA Walters, Y Xiao, ZM Sheng… - Science Translational …, 2021 - science.org
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), is characterized by respiratory distress, multiorgan …

Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19

M Ackermann, SE Verleden, M Kuehnel… - … England Journal of …, 2020 - Mass Medical Soc
Background Progressive respiratory failure is the primary cause of death in the coronavirus
disease 2019 (Covid-19) pandemic. Despite widespread interest in the pathophysiology of …

COVID-19 lung pathogenesis in SARS-CoV-2 autopsy cases

S Valdebenito, S Bessis, D Annane… - Frontiers in …, 2021 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major public health
issue. COVID-19 is considered an airway/multi-systemic disease, and demise has been …

The fatal trajectory of pulmonary COVID-19 is driven by lobular ischemia and fibrotic remodelling

M Ackermann, JC Kamp, C Werlein, CL Walsh… - …, 2022 - thelancet.com
Background COVID-19 is characterized by a heterogeneous clinical presentation, ranging
from mild symptoms to severe courses of disease. 9–20% of hospitalized patients with …

Autopsy-based pulmonary and vascular pathology: pulmonary endotheliitis and multi-organ involvement in COVID-19 associated deaths

M Haberecker, EI Schwarz, P Steiger, K Frontzek… - Respiration, 2022 - karger.com
Background: Findings from autopsies have provided evidence on systemic microvascular
damage as one of the underlying mechanisms of Coronavirus disease 2019 (CO-VID-19) …

The immunopathological and histological landscape of COVID-19-mediated lung injury

G Zarrilli, V Angerilli, G Businello, M Sbaraglia… - International Journal of …, 2021 - mdpi.com
A complete understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) physiopathology and related histopathologic lesions is necessary to improve treatment …

Pathological features of COVID-19-associated lung injury: a preliminary proteomics report based on clinical samples

L Leng, R Cao, J Ma, D Mou, Y Zhu, W Li, L Lv… - … and Targeted Therapy, 2020 - nature.com
The COVID-19 pandemic has emerged as a global health emergency due to its association
with severe pneumonia and relative high mortality. However, the molecular characteristics …

Tracking the time course of pathological patterns of lung injury in severe COVID-19

T Mauad, AN Duarte-Neto, LFF da Silva… - Respiratory …, 2021 - Springer
Background Pulmonary involvement in COVID-19 is characterized pathologically by diffuse
alveolar damage (DAD) and thrombosis, leading to the clinical picture of Acute Respiratory …

Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases

Q Liu, Y Shi, J Cai, Y Duan, R Wang… - National Science …, 2020 - academic.oup.com
Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents
should provide insights into the disease characteristics and facilitate the development of …

Alveolar macrophage dysfunction and cytokine storm in the pathogenesis of two severe COVID-19 patients

C Wang, J Xie, L Zhao, X Fei, H Zhang, Y Tan, X Nie… - …, 2020 - thelancet.com
Background The novel coronavirus pneumonia COVID-19 caused by SARS-CoV-2 infection
could lead to a series of clinical symptoms and severe illnesses, including acute respiratory …