Passive immunotherapy of viral infections:'super-antibodies' enter the fray

LM Walker, DR Burton - Nature Reviews Immunology, 2018 - nature.com
Antibodies have been used for more than 100 years in the therapy of infectious diseases,
but a new generation of highly potent and/or broadly cross-reactive human monoclonal …

Passive antibody therapy for infectious diseases

A Casadevall, E Dadachova, L Pirofski - Nature Reviews Microbiology, 2004 - nature.com
Antibody-based therapies are currently undergoing a renaissance. After being developed
and then largely abandoned in the twentieth century, many antibody preparations are now in …

Recent advances in therapeutic applications of neutralizing antibodies for virus infections: an overview

MG Ali, Z Zhang, Q Gao, M Pan, EG Rowan… - Immunologic …, 2020 - Springer
Antibodies are considered as an excellent foundation to neutralize pathogens and as highly
specific therapeutic agents. Antibodies are generated in response to a vaccine but little use …

Antiviral monoclonal antibodies: can they be more than simple neutralizing agents?

M Pelegrin, M Naranjo-Gomez, M Piechaczyk - Trends in microbiology, 2015 - cell.com
Monoclonal antibodies (mAbs) are increasingly being considered as agents to fight severe
viral diseases. So far, they have essentially been selected and used on the basis of their …

Antibodies in infectious diseases: polyclonals, monoclonals and niche biotechnology

JD Berry, RG Gaudet - New biotechnology, 2011 - Elsevier
Antibody preparations have a long history of providing protection from infectious diseases.
Although antibodies remain the only natural host-derived defense mechanism capable of …

[HTML][HTML] Monoclonal antibodies for prophylactic and therapeutic use against viral infections

L Both, AC Banyard, C van Dolleweerd, E Wright… - Vaccine, 2013 - Elsevier
Neutralizing antibodies play an essential part in antiviral immunity and are instrumental in
preventing or modulating viral diseases. Polyclonal antibody preparations are increasingly …

[HTML][HTML] Preventing infectious disease with passive immunization

L Zeitlin, RA Cone, TR Moench, KJ Whaley - Microbes and infection, 2000 - Elsevier
Antibodies can prevent infectious diseases by providing passive immune protection. Here
we review successful clinical trials of passive immunization and consider some of the unique …

The growth and potential of human antiviral monoclonal antibody therapeutics

WA Marasco, J Sui - Nature biotechnology, 2007 - nature.com
Monoclonal antibodies (mAbs) have long provided powerful research tools for virologists to
understand the mechanisms of virus entry into host cells and of antiviral immunity. Even so …

Passive antibody therapies: progress and continuing challenges

A Casadevall - Clinical Immunology, 1999 - Elsevier
In recent years antibody-based therapies have returned as first-line therapy for a variety of
diverse conditions that include viral infections, inflammatory disorders, and certain …

Tools to therapeutically harness the human antibody response

PC Wilson, SF Andrews - Nature Reviews Immunology, 2012 - nature.com
The natural human antibody response is a rich source of highly specific, neutralizing and
self-tolerant therapeutic reagents. Recent advances have been made in isolating and …