Nucleic acid-based materials showcase an increasing potential for antimicrobial drug
delivery. Although numerous reports on drug-loaded DNA nanoparticles outline their pivotal …

Pseudomonas aeruginosa (PA) is one of the most common multidrug-resistant pathogens
found in clinics, often manifesting as biofilms. However, due to the emergence of superbugs …

There is growing interest in the development of nucleic acid nanostructures as smart
functional materials for applications in drug delivery. Inspired by the diverse physical …

The epidemic of multidrug-resistant Gram-negative bacteria is an ever-growing global
concern. Polymyxin B (PMB), a kind of “old fashioned” antibiotic, has been revived in clinical …

Because of the emergence of antimicrobial resistance to traditional small-molecule drugs,
cationic antimicrobial polymers are appealing targets. Mycobacterium tuberculosis is a …

The persistence of Staphylococcus aureus has been accredited to its ability to escape
immune response via host cell invasion. Despite the efficacy of many antibiotics against S …

Effective accumulation and penetration of antibiotics in the biofilm are critical issues for
bacterial infection treatment. Red blood cells (RBCs) have been widely utilized to hitchhike …

Traditional antibiotics usually sterilize in chemical ways, which may lead to serious drug
resistance. By contrast, peptide-based antibacterial materials are less susceptible to drug …

Pseudomonas aeruginosa (PA) biofilms cause many persistent chronic infections in
humans, especially in cystic fibrosis (CF) patients. The biofilms form a strong barrier which …

Bacterial pathogens continue to impose a tremendous health burden across the globe.
Here, we describe a novel series of polymyxin-based agents grafted with membrane-active …