Serine protease inhibitors restrict host susceptibility to SARS-CoV-2 infections
E Rosendal, IS Mihai, M Becker, D Das, L Frängsmyr… - MBio, 2022 - Am Soc Microbiol
ABSTRACT The coronavirus disease 2019, COVID-19, is a complex disease with a wide
range of symptoms from asymptomatic infections to severe acute respiratory syndrome with …
range of symptoms from asymptomatic infections to severe acute respiratory syndrome with …
Structure, activity and inhibition of human TMPRSS2, a protease implicated in SARS-CoV-2 activation
BJ Fraser, S Beldar, A Seitova, A Hutchinson… - BioRxiv, 2021 - biorxiv.org
ABSTRACT Transmembrane protease, serine 2 (TMPRSS2) has been identified as key host
cell factor for viral entry and pathogenesis of SARS-coronavirus-2 (SARS-CoV-2) …
cell factor for viral entry and pathogenesis of SARS-coronavirus-2 (SARS-CoV-2) …
Structure-based phylogeny identifies avoralstat as a TMPRSS2 inhibitor that prevents SARS-CoV-2 infection in mice
Drugs targeting host proteins can act prophylactically to reduce viral burden early in disease
and limit morbidity, even with antivirals and vaccination. Transmembrane serine protease 2 …
and limit morbidity, even with antivirals and vaccination. Transmembrane serine protease 2 …
Spiking dependence of SARS‐CoV‐2 pathogenicity on TMPRSS2
AZ Abbasi, DA Kiyani, SM Hamid… - Journal of Medical …, 2021 - Wiley Online Library
Epidemiological data shows a discrepancy in COVID‐19 susceptibility and outcomes with
some regions being more heavily affected than others. However, the factors that determine …
some regions being more heavily affected than others. However, the factors that determine …
The Transmembrane protease serine 2 (TMPRSS2) non-protease domains regulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike …
R Strobelt, J Adler, Y Shaul - Viruses, 2023 - mdpi.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters cells by binding
to the angiotensin-converting enzyme 2 (hACE2) receptor. This process is aided by the …
to the angiotensin-converting enzyme 2 (hACE2) receptor. This process is aided by the …
A Review on Expression, Pathological Roles, and Inhibition of TMPRSS2, the Serine Protease Responsible for SARS‐CoV‐2 Spike Protein Activation
SARS‐CoV‐2, the coronavirus responsible for the COVID‐19 pandemic, uses the host cell
membrane receptor angiotensin‐converting enzyme 2 (ACE2) for anchoring its spike …
membrane receptor angiotensin‐converting enzyme 2 (ACE2) for anchoring its spike …
A novel highly potent inhibitor of TMPRSS2-like proteases blocks SARS-CoV-2 variants of concern and is broadly protective against infection and mortality in mice
The COVID-19 pandemic caused by the SARS-CoV-2 virus remains a global public health
crisis. Although widespread vaccination campaigns are underway, their efficacy is reduced …
crisis. Although widespread vaccination campaigns are underway, their efficacy is reduced …
[HTML][HTML] Alpha 1 antitrypsin is an inhibitor of the SARS-CoV-2–priming protease TMPRSS2
NP Azouz, AM Klingler, V Callahan… - Pathogens And …, 2021 - ncbi.nlm.nih.gov
Background: Host proteases have been suggested to be crucial for dissemination of MERS,
SARS-CoV, and SARS-CoV-2 coronaviruses, but the relative contribution of membrane …
SARS-CoV, and SARS-CoV-2 coronaviruses, but the relative contribution of membrane …
Discovery of TMPRSS2 inhibitors from virtual screening as a potential treatment of COVID-19
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has
prompted researchers to pivot their efforts to finding antiviral compounds and vaccines. In …
prompted researchers to pivot their efforts to finding antiviral compounds and vaccines. In …
TMPRSS11D and TMPRSS13 activate the SARS-CoV-2 spike protein
M Kishimoto, K Uemura, T Sanaki, A Sato, WW Hall… - Viruses, 2021 - mdpi.com
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) utilizes host proteases,
including a plasma membrane-associated transmembrane protease, serine 2 (TMPRSS2) to …
including a plasma membrane-associated transmembrane protease, serine 2 (TMPRSS2) to …