17β-Estradiol (E2) controls many aspects of human physiology, including development,
reproduction and homeostasis, through regulation of the transcriptional activity of its cognate …

The biological effects of estrogen (E) in mammalian target tissues are important for
numerous physiological processes. E is known to induce responses in the reproductive tract …

17β-Estradiol (E2) binding induces rapid modification in the conformation of its cognate
receptors (ie, ERα and ERβ). These allosteric changes allow the association of ERs with cell …

To search for endogenous estrogens that may have preferential binding affinity for human
estrogen receptor (ER) α or β subtype and also to gain insights into the structural …

Today we have to consider the existence of two estrogen receptors, a and b, in our attempts
to understand the role of estrogen receptors in physiology and pathology, and to explain the …

The estrogen receptor (ER) mediates most of the biological effects of estrogens at the level
of gene regulation by interacting through its site‐specific DNA and with other coregulatory …

Together with the estrogen receptor (ER) alpha, estrogen receptor beta (ERβ) mediates
many of the physiological effects of estrogens. As ERβ is crucially involved in a variety of …

During the past decade there has been a substantial advance in our understanding of
estrogen signaling both from a clinical as well as a preclinical perspective. Estrogen …

Estrogen receptor beta (ER-β) regulates diverse physiological functions in the human body.
Current studies are confined to ER-β1, and the functional roles of isoforms 2, 4, and 5 …

Abstract 17β‐Estradiol (E2), as the main circulating estrogen hormone, regulates many
tissue and organ functions in physiology. The effects of E2 on cells are mediated by the …