Localization of PPAR isotypes in the adult mouse and human brain

A Warden, J Truitt, M Merriman, O Ponomareva… - Scientific reports, 2016 - nature.com
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that act
as ligand-activated transcription factors. PPAR agonists have well-documented anti …

Localization of PPARδ in murine central nervous system: expression in oligodendrocytes and neurons

JW Woods, M Tanen, DJ Figueroa, C Biswas… - Brain research, 2003 - Elsevier
The peroxisome proliferator-activated receptors (PPARs), PPARδ, PPARγ and PPARα,
comprise a subclass of the supergene family of nuclear receptors. As such they are ligand …

Identification and characterization of PPARα ligands in the hippocampus

A Roy, M Kundu, M Jana, RK Mishra, Y Yung… - Nature chemical …, 2016 - nature.com
Peroxisome proliferator–activated receptor-α (PPARα) regulates hepatic fatty acid
catabolism and mediates the metabolic response to starvation. Recently we found that …

Peroxisome Proliferator‐Activated Receptor β/δ in the Brain: Facts and Hypothesis

MG Hall, L Quignodon, B Desvergne - PPAR research, 2008 - Wiley Online Library
peroxisome proliferator‐activated receptors (PPARs) are nuclear receptors acting as lipid
sensors. Besides its metabolic activity in peripheral organs, the PPAR beta/delta isotype is …

Expression of peroxisome proliferator-activated receptor-γ in key neuronal subsets regulating glucose metabolism and energy homeostasis

DA Sarruf, F Yu, HT Nguyen, DL Williams… - …, 2009 - academic.oup.com
In addition to increasing insulin sensitivity and adipogenesis, peroxisome proliferator-
activated receptor (PPAR)-γ agonists cause weight gain and hyperphagia. Given the central …

Peroxisome proliferator-activated receptor (PPAR) β/δ, a possible nexus of PPARα-and PPARγ-dependent molecular pathways in neurodegenerative diseases …

S Aleshin, M Strokin, M Sergeeva, G Reiser - Neurochemistry international, 2013 - Elsevier
Peroxisome proliferator-activated receptors (PPARα,-β/δ and-γ) are lipid-activated
transcription factors. Synthetic PPARα and PPARγ ligands have neuroprotective properties …

PPARs in the central nervous system: roles in neurodegeneration and neuroinflammation

JM Zolezzi, MJ Santos, S Bastías‐Candia… - Biological …, 2017 - Wiley Online Library
Over 25 years have passed since peroxisome proliferators‐activated receptors (PPARs),
were first described. Like other members of the nuclear receptors superfamily, PPARs have …

Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha,-beta, and-gamma in the adult rat

O Braissant, F Foufelle, C Scotto, M Dauça… - …, 1996 - academic.oup.com
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone
receptor superfamily that can be activated by various xenobiotics and natural fatty acids …

Peroxisome proliferator-activated receptor gamma (PPAR-γ) and neurodegenerative disorders

YC Chen, JS Wu, HD Tsai, CY Huang, JJ Chen… - Molecular …, 2012 - Springer
As the growth of the aging population continues to accelerate globally, increased
prevalence of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's …

Recent Insights on the Role of PPAR-β/δ in Neuroinflammation and Neurodegeneration, and Its Potential Target for Therapy

AK Strosznajder, S Wójtowicz, MJ Jeżyna… - Neuromolecular …, 2021 - Springer
Peroxisome proliferator-activated receptor (PPAR) β/δ belongs to the family of hormone and
lipid-activated nuclear receptors, which are involved in metabolism of long-chain fatty acids …