Characterizing the shared genetic underpinnings of schizophrenia and cardiovascular disease risk factors
L Rødevand, Z Rahman, GFL Hindley… - American Journal of …, 2023 - Am Psychiatric Assoc
Objective: Schizophrenia is associated with increased risk of cardiovascular disease (CVD),
although there is variation in risk among individuals. There are indications of shared genetic …
although there is variation in risk among individuals. There are indications of shared genetic …
Exploring the relationship between schizophrenia and cardiovascular disease: a genetic correlation and multivariable Mendelian randomization study
RR Veeneman, JM Vermeulen… - Schizophrenia …, 2022 - academic.oup.com
Individuals with schizophrenia have a reduced life-expectancy compared to the general
population, largely due to an increased risk of cardiovascular disease (CVD). Clinical and …
population, largely due to an increased risk of cardiovascular disease (CVD). Clinical and …
Evidence for shared genetic aetiology between schizophrenia, cardiometabolic, and inflammation-related traits: genetic correlation and colocalization analyses
Background Schizophrenia commonly co-occurs with cardiometabolic and inflammation-
related traits. It is unclear to what extent the comorbidity could be explained by shared …
related traits. It is unclear to what extent the comorbidity could be explained by shared …
Exploring shared genetic bases and causal relationships of schizophrenia and bipolar disorder with 28 cardiovascular and metabolic traits
BackgroundCardiovascular diseases represent a major health issue in patients with
schizophrenia (SCZ) and bipolar disorder (BD), but the exact nature of cardiometabolic (CM) …
schizophrenia (SCZ) and bipolar disorder (BD), but the exact nature of cardiometabolic (CM) …
[PDF][PDF] Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors
Several lines of evidence suggest that genome-wide association studies (GWASs) have the
potential to explain more of the" missing heritability" of common complex phenotypes …
potential to explain more of the" missing heritability" of common complex phenotypes …
Uncovering the hidden risk architecture of the schizophrenias: confirmation in three independent genome-wide association studies
Objective: The authors sought to demonstrate that schizophrenia is a heterogeneous group
of heritable disorders caused by different genotypic networks that cause distinct clinical …
of heritable disorders caused by different genotypic networks that cause distinct clinical …
[HTML][HTML] Integrated analysis of summary statistics to identify pleiotropic genes and pathways for the comorbidity of schizophrenia and cardiometabolic disease
H Liu, Y Sun, X Zhang, S Li, D Hu, L Xiao… - Frontiers in …, 2020 - frontiersin.org
Genome-wide association studies (GWAS) have identified abundant risk loci associated with
schizophrenia (SCZ), cardiometabolic disease (CMD) including body mass index, coronary …
schizophrenia (SCZ), cardiometabolic disease (CMD) including body mass index, coronary …
Genome‐wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness
Genome‐wide association studies (GWAS) of schizophrenia have yielded more than 100
common susceptibility variants, and strongly support a substantial polygenic contribution of …
common susceptibility variants, and strongly support a substantial polygenic contribution of …
Common variants conferring risk of schizophrenia: a pathway analysis of GWAS data
Unlike the typical analysis of single markers in genome-wide association studies (GWAS),
we incorporated Gene Set Enrichment Analysis (GSEA) and hypergeometric test and …
we incorporated Gene Set Enrichment Analysis (GSEA) and hypergeometric test and …
Association between substance use disorder and polygenic liability to schizophrenia
Background There are high levels of comorbidity between schizophrenia and substance use
disorder, but little is known about the genetic etiology of this comorbidity. Methods We tested …
disorder, but little is known about the genetic etiology of this comorbidity. Methods We tested …