Ferroptosis: mechanisms, biology and role in disease

X Jiang, BR Stockwell, M Conrad - Nature reviews Molecular cell …, 2021 - nature.com
The research field of ferroptosis has seen exponential growth over the past few years, since
the term was coined in 2012. This unique modality of cell death, driven by iron-dependent …

Ferroptosis: Final destination for cancer?

Z Ye, W Liu, Q Zhuo, Q Hu, M Liu, Q Sun… - Cell …, 2020 - Wiley Online Library
Ferroptosis is a recently defined, non‐apoptotic, regulated cell death (RCD) process that
comprises abnormal metabolism of cellular lipid oxides catalysed by iron ions or iron …

[HTML][HTML] Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications

BR Stockwell - Cell, 2022 - cell.com
Ferroptosis, a form of cell death driven by iron-dependent lipid peroxidation, was identified
as a distinct phenomenon and named a decade ago. Ferroptosis has been implicated in a …

Ferroptosis and its potential as a therapeutic target

H Yuan, J Pratte, C Giardina - Biochemical pharmacology, 2021 - Elsevier
Ferroptosis is a recently defined form of programmed cell death that is different from
apoptosis. It is an iron-dependent programmed cell death and the accumulation of lipid …

[HTML][HTML] Ferroptosis in cancer: From molecular mechanisms to therapeutic strategies

Q Zhou, Y Meng, D Li, L Yao, J Le, Y Liu… - … and Targeted Therapy, 2024 - nature.com
Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal
accumulation of iron-dependent membrane-localized lipid peroxides. It acts as an innate …

[HTML][HTML] Targeting ferroptosis opens new avenues for the development of novel therapeutics

S Sun, J Shen, J Jiang, F Wang, J Min - Signal transduction and …, 2023 - nature.com
Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics,
including altered iron homeostasis, reduced defense against oxidative stress, and abnormal …

[HTML][HTML] Ferroptosis: past, present and future

J Li, F Cao, H Yin, Z Huang, Z Lin, N Mao, B Sun… - Cell death & …, 2020 - nature.com
Ferroptosis is a new type of cell death that was discovered in recent years and is usually
accompanied by a large amount of iron accumulation and lipid peroxidation during the cell …

Ferroptosis: From regulation of lipid peroxidation to the treatment of diseases

Y Lv, M Wu, Z Wang, J Wang - Cell Biology and Toxicology, 2023 - Springer
Ferroptosis is a regulated cell death mainly manifested by iron-dependent lipid peroxide
accumulation. The leading cause of ferroptosis is the imbalance of intracellular oxidative …

Zooming in and out of ferroptosis in human disease

X Wang, Y Zhou, J Min, F Wang - Frontiers of Medicine, 2023 - Springer
Ferroptosis is defined as an iron-dependent regulated form of cell death driven by lipid
peroxidation. In the past decade, it has been implicated in the pathogenesis of various …

[HTML][HTML] Ferroptosis as a potential target for cancer therapy

Z Chen, W Wang, SR Abdul Razak, T Han… - Cell death & …, 2023 - nature.com
Ferroptosis is a recently discovered essential type of cell death that is mainly characterized
by iron overload and lipid peroxidation. Emerging evidence suggests that ferroptosis is a …