[HTML][HTML] A novel pathophysiological classification of silicosis models provides some new insights into the progression of the disease

Z Cao, M Song, Y Liu, J Pang, Z Li, X Qi, T Shu… - Ecotoxicology and …, 2020 - Elsevier
Silicosis is caused by massive inhalation of silica-based particles, which leads to pulmonary
inflammation, pulmonary fibrosis and lung dysfunction. Currently, the pathophysiological …

A suitable silicosis mouse model was constructed by repeated inhalation of silica dust via nose

B Li, M Mu, Q Sun, H Cao, Q Liu, J Liu, J Zhang, K Xu… - Toxicology Letters, 2021 - Elsevier
Silicosis as the serious occupational disease is highly necessary to construct a suitable
mouse model for disclosing mechanism of occurrence and development in this disease …

Silica particles disorganize the polarization of pulmonary macrophages in mice

Y Zhao, C Hao, L Bao, D Wang, Y Li, Y Qu… - Ecotoxicology and …, 2020 - Elsevier
Silicosis is a fatal fibrotic lung disease caused by long-term silica particle exposure, in which
pulmonary macrophages play an important role. However, the relationship between …

Dynamic changes of mononuclear phagocytes in circulating, pulmonary alveolar and interstitial compartments in a mouse model of experimental silicosis

GA Xiang, YD Zhang, CC Su, YQ Ma, YM Li… - Inhalation …, 2016 - Taylor & Francis
Context: Silicosis is a devastating, irreversible lung fibrosis condition exposed to crystalline
silica. The mononuclear phagocyte system plays an important role in the pathogenesis of …

Comparative RNA‐Seq transcriptome analysis on silica induced pulmonary inflammation and fibrosis in mice silicosis model

J Chen, Y Yao, X Su, Y Shi, X Song… - Journal of Applied …, 2018 - Wiley Online Library
Silicosis is a long‐established public health issue in developing countries due to
increasingly serious air pollution and poorly implemented occupational safety regulation …

Lipid dysregulation associated with progression of silica-induced pulmonary fibrosis

R Ma, Y Fan, X Huang, J Wang, S Li… - Toxicological …, 2023 - academic.oup.com
Silicosis is an irreversible, progressive, fibrotic lung disease caused by long-term exposure
to dust-containing silica particles at the workplace. Despite the precautions enforced, the …

New insights into pathomechanisms and treatment possibilities for lung silicosis

J Adamcakova, D Mokra - International journal of molecular sciences, 2021 - mdpi.com
Inhalation of silica particles is an environmental and occupational cause of silicosis, a type
of pneumoconiosis. Development of the lung silicosis is a unique process in which the …

Transcriptome profile analysis reveals a silica-induced immune response and fibrosis in a silicosis rat model

H Zhao, Z Jiang, R Lv, X Li, Y Xing, Y Gao, D Lv, Y Si… - Toxicology letters, 2020 - Elsevier
Silicosis is a type of pneumoconiosis caused by the inhalation of silica dust. It is
characterized by inflammation and fibrosis of the lung. Although many studies have reported …

Integrative transcriptomic and proteomic analysis reveals mechanisms of silica-induced pulmonary fibrosis in rats

C Bo, J Zhang, L Sai, Z Du, G Yu, C Li, M Li… - BMC Pulmonary …, 2022 - Springer
Background Silicosis is a systemic disease characterized by persistent inflammation and
incurable pulmonary fibrosis. Although great effort has been made to understand the …

The mechanism and effect of autophagy, apoptosis, and pyroptosis on the progression of silicosis

S Tan, S Chen - International Journal of Molecular Sciences, 2021 - mdpi.com
Silicosis remains one of the most severe pulmonary fibrotic diseases worldwide, caused by
chronic exposure to silica dust. In this review, we have proposed that programmed cell death …