Targeted delivery of butyrate improves glucose homeostasis, reduces hepatic lipid accumulation and inflammation in db/db mice

SS Pedersen, M Prause, C Sørensen, J Størling… - International Journal of …, 2023 - mdpi.com
Butyrate produced by the gut microbiota has beneficial effects on metabolism and
inflammation. Butyrate-producing bacteria are supported by diets with a high fiber content …

Butyrate generated by gut microbiota and its therapeutic role in metabolic syndrome

SC Bridgeman, W Northrop, PE Melton… - Pharmacological …, 2020 - Elsevier
Metabolic syndrome (MetS) and the associated incidence of cardiovascular disease and
type 2 diabetes represents a significant contributor to morbidity and mortality worldwide …

Butyrate reduces high-fat diet-induced metabolic alterations, hepatic steatosis and pancreatic beta cell and intestinal barrier dysfunctions in prediabetic mice

VA Matheus, LCS Monteiro… - Experimental …, 2017 - journals.sagepub.com
In this study, we investigated the effect of diet supplementation with sodium butyrate (5%
w/w), a short-chain fatty acid produced by the intestinal microbiota, on metabolic parameters …

Metabolic responses to butyrate supplementation in LF-and HF-fed mice are cohort-dependent and associated with changes in composition and function of the gut …

S Lee, TA Knotts, ML Goodson, M Barboza, E Wudeck… - Nutrients, 2020 - mdpi.com
The gut microbiota and associated metabolites have emerged as potential modulators of
pathophysiological changes in obesity and related metabolic disorders. Butyrate, a product …

Dietary butyrate suppresses inflammation through modulating gut microbiota in high-fat diet-fed mice

S Zhai, S Qin, L Li, L Zhu, Z Zou… - FEMS microbiology …, 2019 - academic.oup.com
Butyrate, a key metabolite fermented by gut microbiota mainly from undigested
carbohydrates such as dietary fibers is widely used as feed additive. However, mechanisms …

Butyrate to combat obesity and obesity‐associated metabolic disorders: Current status and future implications for therapeutic use

T van Deuren, EE Blaak, EE Canfora - Obesity Reviews, 2022 - Wiley Online Library
Evidence is increasing that disturbances in the gut microbiome may play a significant role in
the etiology of obesity and type 2 diabetes. The short chain fatty acid butyrate, a major end …

Protective role of butyrate in obesity and diabetes: New insights

A Mayorga-Ramos, C Barba-Ostria… - Frontiers in …, 2022 - frontiersin.org
Studies in human microbiota dysbiosis have shown that short-chain fatty acids (SCFAs) like
propionate, acetate, and particularly butyrate, positively affect energy homeostasis …

Anti-diabetic Effects of Clostridium butyricum CGMCC0313.1 through Promoting the Growth of Gut Butyrate-producing Bacteria in Type 2 Diabetic Mice

L Jia, D Li, N Feng, M Shamoon, Z Sun, L Ding… - Scientific reports, 2017 - nature.com
Patients with type 2 diabetes (T2D) have decreased butyrate-producing bacteria. We
hypothesized that supplementation with butyrate-producing bacteria may exert beneficial …

Therapeutic potential of butyrate for treatment of type 2 diabetes

T Arora, V Tremaroli - Frontiers in endocrinology, 2021 - frontiersin.org
Metagenomics studies have shown that type 2 diabetes (T2D) is associated with an altered
gut microbiota. Whereas different microbiota patterns have been observed in independent …

Butyrate supplementation at high concentrations alters enteric bacterial communities and reduces intestinal inflammation in mice infected with Citrobacter rodentium

JA Jiminez, TC Uwiera, DW Abbott, RRE Uwiera… - MSphere, 2017 - Am Soc Microbiol
Butyrate is a short-chain fatty acid by-product of the microbial fermentation of dietary
fermentable materials in the large intestine; it is the main energy source for enterocyte …