Analysis of copy number variations at 15 schizophrenia-associated loci
E Rees, JTR Walters, L Georgieva, AR Isles… - The British Journal of …, 2014 - cambridge.org
BackgroundA number of copy number variants (CNVs) have been suggested as
susceptibility factors for schizophrenia. For some of these the data remain equivocal, and the …
susceptibility factors for schizophrenia. For some of these the data remain equivocal, and the …
New copy number variations in schizophrenia
C Magri, E Sacchetti, M Traversa, P Valsecchi… - PloS one, 2010 - journals.plos.org
Genome-wide screenings for copy number variations (CNVs) in patients with schizophrenia
have demonstrated the presence of several CNVs that increase the risk of developing the …
have demonstrated the presence of several CNVs that increase the risk of developing the …
Copy number variation in schizophrenia in the Japanese population
M Ikeda, B Aleksic, G Kirov, Y Kinoshita… - Biological …, 2010 - Elsevier
BACKGROUND: Copy number variants (CNVs) have been shown to increase the risk to
develop schizophrenia. The best supported findings are at 1q21. 1, 15q11. 2, 15q13. 3, and …
develop schizophrenia. The best supported findings are at 1q21. 1, 15q11. 2, 15q13. 3, and …
Copy number variations in schizophrenia: critical review and new perspectives on concepts of genetics and disease
AS Bassett, SW Scherer… - American Journal of …, 2010 - Am Psychiatric Assoc
Objective Structural variations of DNA, such as copy number variations (CNVs), are
recognized to contribute both to normal genomic variability and to risk for human diseases …
recognized to contribute both to normal genomic variability and to risk for human diseases …
Support for the involvement of large copy number variants in the pathogenesis of schizophrenia
G Kirov, D Grozeva, N Norton, D Ivanov… - Human molecular …, 2009 - academic.oup.com
We investigated the involvement of rare (< 1%) copy number variants (CNVs) in 471 cases
of schizophrenia and 2792 controls that had been genotyped using the Affymetrix …
of schizophrenia and 2792 controls that had been genotyped using the Affymetrix …
CNV analysis in a large schizophrenia sample implicates deletions at 16p12.1 and SLC1A1 and duplications at 1p36.33 and CGNL1
E Rees, JTR Walters, KD Chambert… - Human molecular …, 2014 - academic.oup.com
Large and rare copy number variants (CNVs) at several loci have been shown to increase
risk for schizophrenia. Aiming to discover novel susceptibility CNV loci, we analyzed 6882 …
risk for schizophrenia. Aiming to discover novel susceptibility CNV loci, we analyzed 6882 …
Copy number variants in schizophrenia: confirmation of five previous findings and new evidence for 3q29 microdeletions and VIPR2 duplications
Objective: To evaluate previously reported associations of copy number variants (CNVs)
with schizophrenia and to identify additional associations, the authors analyzed CNVs in the …
with schizophrenia and to identify additional associations, the authors analyzed CNVs in the …
[HTML][HTML] Independent estimation of the frequency of rare CNVs in the UK population confirms their role in schizophrenia
BACKGROUND: Several large, rare chromosomal copy number variants (CNVs) have
recently been shown to increase risk for schizophrenia and other neuropsychiatric disorders …
recently been shown to increase risk for schizophrenia and other neuropsychiatric disorders …
Copy number variation in schizophrenia in Sweden
JP Szatkiewicz, C O'Dushlaine, G Chen… - Molecular …, 2014 - nature.com
Schizophrenia (SCZ) is a highly heritable neuropsychiatric disorder of complex genetic
etiology. Previous genome-wide surveys have revealed a greater burden of large, rare copy …
etiology. Previous genome-wide surveys have revealed a greater burden of large, rare copy …
Rare copy number variants: a point of rarity in genetic risk for bipolar disorder and schizophrenia
D Grozeva, G Kirov, D Ivanov, IR Jones… - Archives of general …, 2010 - jamanetwork.com
Context Recent studies suggest that copy number variation in the human genome is
extensive and may play an important role in susceptibility to disease, including …
extensive and may play an important role in susceptibility to disease, including …