Whether and how regulation of genes and pathways contributes to physiological aging is
topic of intense scientific debate. By performing an RNA expression-based screen for genes …

The deregulation of metabolism is a hallmark of aging. As such, changes in the expression
of metabolic genes and the profiles of amino acid levels are features associated with aging …

Studies of mutations affecting lifespan in Caenorhabditis elegans show that mitochondrial
generation of reactive oxygen species (ROS) plays a major causative role in organismal …

Gut microbes play diverse roles in modulating host fitness, including longevity; however, the
molecular mechanisms underlying their mediation of longevity remain poorly understood …

Abstract d-Glucosamine (GlcN) is a freely available and commonly used dietary supplement
potentially promoting cartilage health in humans, which also acts as an inhibitor of …

The restriction of calories, branched-chain amino acids, and methionine have all been
shown to extend lifespan in model organisms. Recently, glycine was found to boost …

Metformin, a widely prescribed first‐line drug for the treatment of type II diabetes mellitus,
has been shown to extend lifespan and delay the onset of age‐related diseases. The …

Glutamine is a conditionally essential amino acid involved in energy production and redox
homeostasis. Aging is commonly characterized by energy generation reduction and redox …

Reactive α-dicarbonyls (α-DCs), like methylglyoxal (MGO), accumulate with age and have
been implicated in aging and various age-associated pathologies, such as diabetic …

Ageing has been defined as a global decline in physiological function depending on both
environmental and genetic factors. Here we identify gene transcripts that are similarly …