Multicellular tumor spheroids (MCTs) have been employed in biomedical fields owing to
their advantage in designing a three-dimensional (3D) solid tumor model. For controlling …

Three dimensional multicellular aggregate, also referred to as cell spheroid or microtissue,
is an indispensable tool for in vitro evaluating antitumor activity and drug efficacy. Compared …

Improved in vitro models are needed to better understand cancer progression and bridge
the gap between in vitro proof-of-concept studies, in vivo validation, and clinical application …

Abstract The three-dimensional (3D) multicellular tumor spheroids (MCTs) model is
becoming an essential tool in cancer research as it expresses an intermediate complexity …

The present article highlights the rationale, potential and flexibility of tumor spheroid mono-
and cocultures for implementation into state of the art anti-cancer therapy test platforms …

Nanomedicine has emerged as a promising therapeutic approach, but its translation to the
clinic has been hindered by the lack of cellular models to anticipate how tumor cells will …

Biomedical research requires both in vitro and in vivo studies in order to explore disease
processes or drug interactions. Foundational investigations have been performed at the …

Three-dimensional (3D) multicellular spheroid models can recapitulate the human tumour
microenvironment with more accuracy than conventional cell culture models, as they include …

Most cancer biologists still rely on conventional two-dimensional (2D) monolayer culture
techniques to test in vitro anti-tumor drugs prior to in vivo testing. However, the vast majority …

Over the last few decades, the most popular platform to perform high-throughput screening
for viable anti-neoplastic compounds has been monolayer cell culture. However, cells in …