Matrix metalloproteinases are important regulators of extracellular matrix molecules and cell-
cell signaling. Antibodies to matrix metalloproteinase 3 (MMP3) recognize molecules at the …

The extracellular matrix at the neuromuscular junction plays many roles. The matrix plays a
structural role in that it maintains the spatial relationship between the muscle cell, Schwann …

Agrin is a heparan sulfate proteoglycan, which plays an essential role in the development
and maintenance of the neuromuscular junction. Agrin is a stable component of the synaptic …

The extracellular matrix surrounding the neuromuscular junction is a highly specialized and
dynamic structure. Matrix metalloproteinases are enzymes that sculpt the extracellular …

Agrin, a heparin sulfate proteoglycan, is an integral member of the synaptic basal lamina
and plays a critical role in the formation and maintenance of the neuromuscular junction …

Matrix metalloproteinases (MMPs) have been proposed to remodel the extracellular
environment of neurons. Here, we report that the metalloproteinase membrane-type 5 MMP …

The vertebrate neuromuscular junction (NMJ) remains the best‐studied model for
understanding the mechanisms involved in synaptogenesis, due to its relatively large size …

Nerve crush or axotomy results in a transient or long‐term denervation accompanied by
remodelling in nerve, muscle and neuromuscular junctions. These changes include an …

Motor neurons, skeletal muscles, and perisynaptic Schwann cells interact with extracellular
matrix (ECM) to form the tetrapartite synapse in the peripheral nervous system. Dynamic …

During the initial stage of neuromuscular junction (NMJ) formation, nerve-derived agrin
cooperates with muscle-autonomous mechanisms in the organization and stabilization of a …