Phosphatidic acid in neuronal development: a node for membrane and cytoskeleton rearrangements

MR Ammar, N Kassas, MF Bader, N Vitale - Biochimie, 2014 - Elsevier
Phosphatidic acid (PA) is the simplest phospholipid naturally existing in all-living organisms.
It constitutes only a minor fraction of the total cell lipids but has attracted considerable …

Phosphatidic acid: from pleiotropic functions to neuronal pathology

E Tanguy, Q Wang, H Moine, N Vitale - Frontiers in cellular …, 2019 - frontiersin.org
Among the cellular lipids, phosphatidic acid (PA) is a peculiar one as it is at the same time a
key building block of phospholipid synthesis and a major lipid second messenger conveying …

Phosphatidic acid–a simple phospholipid with multiple faces

J Zegarlinska, M Piaścik, AF Sikorski… - Acta Biochimica …, 2018 - abp.ptbioch.edu.pl
Phosphatidic acid (PA) is the simplest glycerophospholipid naturally occurring in living
organisms, and even though its content among other cellular lipids is minor, it is drawing …

Lysophosphatidic acid (LPA) is a novel extracellular regulator of cortical neuroblast morphology

N Fukushima, JA Weiner, J Chun - Developmental biology, 2000 - Elsevier
During cerebral cortical neurogenesis, neuroblasts in the ventricular zone (VZ) undergo a
shape change termed “interkinetic nuclear migration” whereby cells alternate between …

Phosphatidic acid: an emerging versatile class of cellular mediators

SC Kim, X Wang - Essays in Biochemistry, 2020 - portlandpress.com
Lipids function not only as the major structural components of cell membranes, but also as
molecular messengers that transduce signals to trigger downstream signaling events in the …

Lysophosphatidic acid influences the morphology and motility of young, postmitotic cortical neurons

N Fukushima, JA Weiner, D Kaushal… - Molecular and Cellular …, 2002 - Elsevier
Lysophosphatidic acid (LPA) is a bioactive lysophospholipid that produces process
retraction and cell rounding through its cognate receptors in neuroblastoma cell lines …

What makes the bioactive lipids phosphatidic acid and lysophosphatidic acid so special?

EE Kooijman, KM Carter, EG van Laar, V Chupin… - Biochemistry, 2005 - ACS Publications
Phosphatidic acid and lysophosphatidic acid are minor but important anionic bioactive lipids
involved in a number of key cellular processes, yet these molecules have a simple …

Phosphatidic acid: Mono-and poly-unsaturated forms regulate distinct stages of neuroendocrine exocytosis

E Tanguy, A Wolf, M Montero-Hadjadje… - Advances in biological …, 2021 - Elsevier
Lipids have emerged as important actors in an ever-growing number of key functions in cell
biology over the last few years. Among them, glycerophospholipids are major constituents of …

Phosphatidic acid: From biophysical properties to diverse functions

H Zhou, Y Huo, N Yang, T Wei - The FEBS Journal, 2024 - Wiley Online Library
Phosphatidic acid (PA), the simplest phospholipid, acts as a key metabolic intermediate and
second messenger that impacts diverse cellular and physiological processes across species …

Biophysics and function of phosphatidic acid: a molecular perspective

EE Kooijman, KNJ Burger - Biochimica et Biophysica Acta (BBA)-Molecular …, 2009 - Elsevier
Phosphatidic acid is the simplest (diacyl) glycerophospholipid present in cells and is now a
well established second messenger with direct biological functions. It is specifically …