Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression

RC Culverhouse, NL Saccone, AC Horton, Y Ma… - Molecular …, 2018 - nature.com
The hypothesis that the S allele of the 5-HTTLPR serotonin transporter promoter region is
associated with increased risk of depression, but only in individuals exposed to stressful …

The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation

K Karg, M Burmeister, K Shedden… - Archives of general …, 2011 - jamanetwork.com
Objective: To perform a meta-analysis including all relevant studies exploring the interaction.
Data Sources: We identified studies published through November 2009 in PubMed. Study …

Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis

N Risch, R Herrell, T Lehner, KY Liang, L Eaves, J Hoh… - Jama, 2009 - jamanetwork.com
Context Substantial resources are being devoted to identify candidate genes for complex
mental and behavioral disorders through inclusion of environmental exposures following the …

An update on the interaction between the serotonin transporter promoter variant (5-HTTLPR), stress and depression, plus an exploration of non-confirming findings

CF Sharpley, SKA Palanisamy, NS Glyde… - Behavioural brain …, 2014 - Elsevier
In the three years since the most recent meta-analysis of the association between the
serotonin transported promoter polymorphism (5-HTTLPR), stress and the development of …

No interaction between the serotonin transporter polymorphism (5‐HTTLPR) and childhood adversity or recent stressful life events on symptoms of depression …

P Chipman, AF Jorm, M Prior, A Sanson… - American Journal of …, 2007 - Wiley Online Library
In this study we investigated interactions between the 5‐HTTLPR genotype and
environmental risk factors (G× E) on symptoms of depression in two large Australian …

The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression

NA Gillespie, JB Whitfield, BEN Williams… - Psychological …, 2005 - cambridge.org
Background. Serotonin is a good candidate for major depression. We attempted to replicate
the study by Caspi and colleagues [Science (2003) 301, 386–389] which reported a …

The serotonin transporter gene-linked polymorphic region (5-HTTLPR) and cortisol stress reactivity: a meta-analysis

R Miller, M Wankerl, T Stalder, C Kirschbaum… - Molecular …, 2013 - nature.com
Recent meta-analyses have stimulated an active debate on whether the serotonin
transporter gene-linked polymorphic region (5-HTTLPR) is associated with an elevated …

Effects of environmental stress and gender on associations among symptoms of depression and the serotonin transporter gene linked polymorphic region (5-HTTLPR)

BH Brummett, SH Boyle, IC Siegler, CM Kuhn… - Behavior genetics, 2008 - Springer
The short (s) variant of the serotonin transporter (5-HTT) gene linked functional polymorphic
region (5-HTTLPR) is associated with depression. Stressful life events, gender, and race …

Interaction between the 5-HTTLPR serotonin transporter polymorphism and environmental adversity for mood and anxiety psychopathology: evidence from a high …

M Laucht, J Treutlein, D Blomeyer… - International Journal …, 2009 - academic.oup.com
Previous research examining gene–environment interaction (G× E) with regard to
vulnerability to depression and anxiety has yielded conflicting results. The present study was …

The serotonin transporter polymorphism (5‐HTTLPR): allelic variation and links with depressive symptoms

N Goldman, DA Glei, YH Lin… - Depression and …, 2010 - Wiley Online Library
Background: We compare the genotype distribution for the serotonin transporter
polymorphism (5‐HTTLPR) in a sample of older Taiwanese adults with samples of various …